26-Week carcinogenicity study of di-isodecyl phthalate by dietary administration to CB6F1-rasH2 transgenic mice
| Autor: | Woo-Chan Son, Wan-Seob Cho, Sue Nie Park, Beom Seok Han, Jayoung Jeong, Mina Choi |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Carcinogenicity Tests Health Toxicology and Mutagenesis Phthalic Acids Administration Oral Mice Transgenic Biology Toxicology Adenoma Liver Cell Muscle hypertrophy Mice chemistry.chemical_compound Liver Neoplasms Experimental Diethylhexyl Phthalate Internal medicine medicine Animals Clofibrate Phthalate Methylnitrosourea General Medicine Hepatocellular adenoma Hyperplasia medicine.disease Disease Models Animal Genes ras Pyrimidines Endocrinology medicine.anatomical_structure Basophilia chemistry Hepatocyte Toxicity Carcinogens Female medicine.drug |
| Zdroj: | Archives of Toxicology. 85:59-66 |
| ISSN: | 1432-0738 0340-5761 |
| Popis: | This study examined the carcinogenic potential of di-isodecyl phthalate (DIDP) in rasH2 mice. DIDP was administered to 15 rasH2 mice/gender/group at dietary levels of 0, 0.1, 0.33, or 1% and 15 wild-type mice/gender/group at dietary levels of 0 and 1% for 26 weeks. Non-neoplastic changes were observed in the liver (parenchymal inflammation, fatty changes, diffuse hepatocyte hypertrophy with eosinophilic granules and focal necrosis) and kidneys (tubular basophilia and tubular hyperplasia) after administration of DIDP in the rasH2 and wild-type mice. In the neoplastic lesions, there were a higher number of hepatocellular adenomas in the male rasH2 mice receiving 1% DIDP, compared with the findings in the liver of control rasH2 mice or wild-type mice. The incidence of hepatocellular adenomas in the 0.1, 0.33, and 1% DIDP exposed rasH2 mice was 7% (1/15), 7% (1/15), and 33% (5/15), respectively. This study adds a set of results for an additional test chemical for the performance of the rasH2 short-term transgenic model to the existing database of 3 compounds (WY-14643, DEHP, and clofibrate) tested in the ILSI/HESI ACT project. |
| Databáze: | OpenAIRE |
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