Prevalence and Severity of Neuropsychiatric Symptoms in Early- Versus Late-Onset Alzheimer’s Disease
| Autor: | Megan Pritchard, Frances Wilson-Morkeh, Amala Jesu, Sarah Baillon, Latha Velayudhan, Amy Gasper |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Sleep Wake Disorders Pediatrics medicine.medical_specialty Late onset Behavioral Symptoms Disease Anxiety Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Alzheimer Disease London mental disorders caregiver stress Prevalence Humans Medicine Early-onset Alzheimer's disease Age of Onset Neuropsychiatry Inventory Aged Aged 80 and over 030214 geriatrics business.industry General Neuroscience early-onset Alzheimer’s disease Middle Aged medicine.disease Irritable Mood Psychiatry and Mental health Clinical Psychology Caregivers Caregiver stress Female neuropsychiatric symptoms Geriatrics and Gerontology business Alzheimer’s disease Stress Psychological 030217 neurology & neurosurgery |
| Zdroj: | Baillon, S, Gasper, A, Wilson-Morkeh, F, Pritchard, M, Jesu, A & Velayudhan, L 2019, ' Prevalence and Severity of Neuropsychiatric Symptoms in Early-Versus Late-Onset Alzheimer's Disease ', American Journal of Alzheimer's Disease & Other Dementias, vol. 34, no. 7-8, pp. 433-438 . https://doi.org/10.1177/1533317519841191 |
| ISSN: | 1938-2731 1533-3175 |
| Popis: | Background: The study aimed to compare neuropsychiatric symptoms (NPS) in people with early-onset Alzheimer’s disease (EOAD) and late-onset AD (LOAD). Methods: Fifty-six participants with LOAD and 24 participants with EOAD having mild dementia were assessed for NPS for their frequency, severity, and caregiver distress as measured by Neuropsychiatry Inventory (NPI) along with assessments of cognition and functional dependence. Results: Participants with EOAD and LOAD were not significantly different for total NPI score ( P = .057). Early-onset Alzheimer disease had greater prevalence of all the NPS except apathy. Participants with EOAD were significantly worse on anxiety ( P = .03), irritability ( P = .01), and sleep ( P < .01) subscales and their carers significantly more distressed by their irritability ( P = .002) and sleeping patterns ( P = .005). Regression analysis showed that higher NPI score was associated with longer duration of illness in EOAD and higher functional dependence in LOAD. Conclusions: The NPS severity was similar between EOAD and LOAD although EOAD had higher symptom prevalence and carer distress. |
| Databáze: | OpenAIRE |
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