An extensive pattern of atypical neural speech-sound discrimination in newborns at risk of dyslexia

Autor: Anja Thiede, Paula Virtala, Kaija Mikkola, Minna Huotilainen, Iina Ala-Kurikka, Paavo H.T. Leppänen, Eino Partanen, Teija Kujala
Přispěvatelé: Cognitive Brain Research Unit, Department of Psychology and Logopedics, DyslexiaBaby, Language Acquisition, Representation, and Processing (L.A.R.P.), Department of Education, CICERO Learning, AGORA for the study of social justice and equality in education -research centre, HUS Children and Adolescents, Children's Hospital, University of Helsinki, Brain, Music and Learning
Rok vydání: 2018
Předmět:
6162 Cognitive science
Male
Speech sound
Audiology
Event-related potential (ERP)
Dyslexia
0302 clinical medicine
EARLY LANGUAGE-ACQUISITION
newborn
Medicine
FAMILIAL RISK
Auditory
BRAIN RESPONSES
05 social sciences
event-related potential (ERP)
Electroencephalography
Sensory Systems
Language development
Neurology
Laterality
Evoked Potentials
Auditory
Speech Perception
Female
Analysis of variance
speech sound
psychological phenomena and processes
medicine.medical_specialty
515 Psychology
MISMATCH NEGATIVITY MMN
CORTICAL RESPONSES
EVENT-RELATED POTENTIALS
GENETIC RISK
behavioral disciplines and activities
050105 experimental psychology
03 medical and health sciences
Speech discrimination
Event-related potential
Phonetics
Physiology (medical)
Vowel
otorhinolaryngologic diseases
dysleksia
Humans
Speech
0501 psychology and cognitive sciences
auditory
AUDITORY-DISCRIMINATION
Mismatch response (MMR)
vastasyntyneet
Auditory Cortex
business.industry
puheääni
3112 Neurosciences
Infant
Newborn
Newborn
mismatch response (MMR)
medicine.disease
ta3124
Pseudoword
PHONEME MISMATCH
Acoustic Stimulation
DEVELOPMENTAL DYSLEXIA
Neurology (clinical)
business
030217 neurology & neurosurgery
Zdroj: Thiede, A, Virtala, P, Ala-Kurikka, I, Partanen, E, Huotilainen, M, Mikkola, K, Leppänen, P & Kujala, T 2019, ' An extensive pattern of atypical neural speech-sound discrimination in newborns at risk of dyslexia ', Clinical Neurophysiology, vol. 130, no. 5, pp. 634-646 . https://doi.org/10.1016/j.clinph.2019.01.019
ISSN: 1872-8952
DOI: 10.1016/j.clinph.2019.01.019
Popis: Objective: Identifying early signs of developmental dyslexia, associated with deficient speech-sound processing, is paramount to establish early interventions. We aimed to find early speech-sound processing deficiencies in dyslexia, expecting diminished and atypically lateralized event-related potentials (ERP) and mismatch responses (MMR) in newborns at dyslexia risk. Methods: ERPs were recorded to a pseudoword and its variants (vowel-duration, vowel-identity, and syllable-frequency changes) from 88 newborns at high or no familial risk. The response significance was tested, and group, laterality, and frontality effects were assessed with repeated-measures ANOVA. Results: An early positive and right-lateralized ERP component was elicited by standard pseudowords in both groups, the response amplitude not differing between groups. Early negative MMRs were absent in the at-risk group, and MMRs to duration changes diminished compared to controls. MMRs to vowel changes had significant laterality x group interactions resulting from right-lateralized MMRs in controls. Conclusions: The MMRs of high-risk infants were absent or diminished, and morphologically atypical, suggesting atypical neural speech-sound discrimination. Significance: This atypical neural basis for speech discrimination may contribute to impaired language development, potentially leading to future reading problems. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
Databáze: OpenAIRE
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