Synthesis of novel selenotetrazole purine derivatives and their potential chemotherapeutic activities
| Autor: | Zuhal Gercek, Gulay Dilek, Ali Dişli, Ishak Ozel Tekin, Burak Coban |
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| Rok vydání: | 2020 |
| Předmět: |
Purine
DNA synthesis 010405 organic chemistry Chemistry Organic Chemistry Cell cycle 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Biochemistry Cell culture Agarose gel electrophoresis Cytotoxic T cell General Pharmacology Toxicology and Pharmaceutics Purine metabolism DNA |
| Zdroj: | Medicinal Chemistry Research. 30:84-97 |
| ISSN: | 1554-8120 1054-2523 |
| DOI: | 10.1007/s00044-020-02641-1 |
| Popis: | The development of novel chemotherapeutic agents is indispensable to improve cancer treatment. One of the conventional approaches toward the synthesis of anticancer agents is the design of a compound whose structure is similar to purines found in DNA. In this study, a series of novel artificial purine nucleosides bearing selenotetrazole pharmacophore, 4a–4h, were synthesized. In order to get preliminary information about their cytotoxic activities, the interaction of compounds with DNA was investigated by UV titration and agarose gel electrophoresis and transcription inhibition studies were performed. The cytotoxic effects of the compounds against B16 melanoma, OV90 ovarian cancer, JM1 lymphoma cell lines, and PHA-induced peripheral blood lymphocytes were also investigated. In cell assay studies, the effects of the compounds on synthesis and mitosis stage of cell cycle were compared by flow cytometry. Although none of the compounds synthesized interacted with DNA and exhibited transcription inhibition, all of them significantly inhibited DNA synthesis phase and showed cytotoxic activity on cancer and proliferating cells. |
| Databáze: | OpenAIRE |
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