Diagnostic and Therapeutic Dilemmas in Rapidly Progressive Sensorineural Hearing Loss and Sudden Deafness a Reappraisal of Immune Reactivity in Inner Ear Disorders
| Autor: | J. E. Veldman, Takehiro Hanada, Frits Meeuwsen |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Pathology
medicine.medical_specialty Hearing loss Hearing Loss Sensorineural Blotting Western Cross Reactions Autoimmune Diseases Epitopes Western blot Antigen otorhinolaryngologic diseases Humans Medicine Cyclophosphamide Cochlea Immunosuppression Therapy biology medicine.diagnostic_test business.industry Cranial nerves General Medicine Hearing Loss Sudden medicine.disease Otorhinolaryngology biology.protein Etiology Prednisone Sensorineural hearing loss Antibody medicine.symptom business |
| Zdroj: | Acta Oto-Laryngologica. 113:303-306 |
| ISSN: | 1651-2251 0001-6489 |
| DOI: | 10.3109/00016489309135813 |
| Popis: | Sera from 76 patients with a clinical diagnosis of idiopathic rapidly progressive sensorineural hearing loss (SNHL) (n = 15), sudden deafness (n = 31) and with other etiologies of their hearing loss (n = 30) were analysed by western blot assay. Seventy-three percent of the cases with rapidly progressive SNHL had cross-reacting antibodies (27, 45, 50, 68 kD). The overall response to immunoprogressive therapy was effective in only 50% of cases. Sixty-five percent of the patients with sudden deafness also had cross-reacting antibodies (27, 45, 50, 80 kD). In these cases steroid therapy was more effective in re-establishing the hearing than no treatment, regardless of the western blot outcome. Spontaneous recovery occurred in approx. 50% of cases, but only in those with a positive assay. The antigenic epitopes detected with immunoblotting were not cochlea specific; they were also found in protein extracts of other organs (cranial nerves, kidney, brain). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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