Paving the way for successful islet encapsulation
| Autor: | Efstathia Papageorgiou, Dimitris Hatziavramidis, Nikos G. Dimitrioglou, Theodore Karatzas, Maria Kanelli |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pharmacology geography geography.geographical_feature_category business.industry Insulin medicine.medical_treatment Islets of Langerhans Transplantation Bioinformatics Islet Encapsulation (networking) 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Insulin-Secreting Cells Drug Discovery Medicine Animals Humans Pancreatic islet transplantation Donor shortage business Stem cell biology |
| Zdroj: | Drug discovery today. 24(3) |
| ISSN: | 1878-5832 |
| Popis: | Type 1 diabetes mellitus (T1DM) is a disorder that decimates pancreatic β-cells which produce insulin. Direct pancreatic islet transplantation cannot serve as a widespread therapeutic modality owing to the need for lifelong immunosuppression and donor shortage. Therefore, several encapsulation techniques have been developed to enclose the islets in semipermeable vehicles that will allow oxygen and nutrient input as well as insulin, other metabolites and waste output, while accomplishing immunoisolation. Although encapsulation technology continues to face significant obstacles, recent advances in material science, stem cell biology and immunology potentially serve as pathways to success. This review summarizes the accomplishments of the past 5 years. |
| Databáze: | OpenAIRE |
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