Metamorphosis of prostate specific membrane antigen (PSMA) inhibitors

Autor: Zahra Nikfarjam, Farshid Zargari, Alireza Nowroozi, Omid Bavi
Rok vydání: 2022
Předmět:
Zdroj: Biophys Rev
ISSN: 1867-2469
1867-2450
Popis: Prostate-specific membrane antigen (PSMA), also called glutamate carboxypeptidase II (GCP(II)), is a Zn-dependent metalloprotease that is known as a well prostate cancer indication and a potential targeting towards anti-cancer medicines and drug delivery. Because of its centrality in the diagnostics and treatment of prostate cancer, several types of inhibitors are designed with particular scaffolds. In this study, important groups of related inhibitors as well as reported experimental and computational studies are being reviewed, in which we examined three functional groups on each group of structures. The importance of computational biochemistry and the necessity of extensive research in this area on PSMA and its effective ligands are recommended.
Databáze: OpenAIRE
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