Detectability of phencyclidine and 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid in adulterated urine by radioimmunoassay and fluorescence polarization immunoassay
| Autor: | P Nyman, D von Minden, William E. Bronner |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Bleach
Potassium Compounds Health Toxicology and Mutagenesis Sodium Radioimmunoassay chemistry.chemical_element Phencyclidine Urine Toxicology Analytical Chemistry chemistry.chemical_compound mental disorders Fluorescence Polarization Immunoassay medicine False positive paradox Hydroxides Environmental Chemistry Humans False Positive Reactions Dronabinol Adulterant Potassium hydroxide Chemical Health and Safety Chromatography medicine.diagnostic_test Chemistry organic chemicals nutritional and metabolic diseases Reproducibility of Results Reference Standards nervous system diseases Immunoassay Potassium |
| Zdroj: | Journal of analytical toxicology. 14(6) |
| ISSN: | 0146-4760 |
| Popis: | The ability to alter immunoassay test results by the addition of some commonly available chemicals to drug-positive and drug-negative urine specimens was investigated. Urine specimens containing either phencyclidine (PCP) or 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid (9-THC-COOH) were adulterated with sodium chloride, bleach, vinegar, potassium hydroxide, liquid soap, 2-propanol, and ammonia. Subsequent analyses by radioimmunoassay (RIA) and fluorescence polarization immunoassay (FPIA) demonstrated false positive and false negative results with some adulterants. Radioimmunoassay false positives occurred with potassium hydroxide (PCP and THC-COOH assays) and bleach (THC-COOH assay) adulterants. Bleach (PCP assay) and soap (THC-COOH assay) additives resulted in false negative analyses by RIA. No adulterant caused FPIA false positives. FPIA false negatives occurred with bleach (PCP and THC-COOH assays) and potassium hydroxide (PCP assay) adulterants. |
| Databáze: | OpenAIRE |
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