Macrophage accumulation at a site of renal inflammation is dependent on the M-CSF/c-fms pathway

Autor: Yannick Le Meur, Prudence A. Hill, Gregory H Tesch, Wei Mu, Rita Foti, David J. Nikolic-Paterson, Robert C. Atkins
Rok vydání: 2002
Předmět:
Zdroj: Monash University
ISSN: 1938-3673
0741-5400
DOI: 10.1189/jlb.72.3.530
Popis: Production of macrophage-colony stimulating factor (M-CSF), the major macrophage growth factor, is increased in tissues during inflammation. Therefore, w determined whether M-CSF, acting through its receptor c-fms, contributes to macrophage accumulation at a site of tissue injury. Daily treatment with anti-c-fms or control antibody was given to mice with renal inflammation resulting from unilateral ureteric obstruction (UUO). Following UUO, kidney M-CSF mRNA increased in association with macrophage accumulation (days 1, 5, and 10) and local macrophage proliferation (days 5 and 10). Anti-c-fms treatment caused a minor inhibition of monocyte recruitment at day 1, reduced macrophage accumulation by 75% at day 10, but did not affect blood monocyte counts or the CD4 and CD8 lymphocytic infiltrate. Prevention of macrophage accumulation by anti-c-fms treatment was associated with a 90% reduction in local macrophage proliferation at days 5 and 10 without evidence of increased macrophage apoptosis. Therefore, M-CSF/c-fms signaling plays a key role in macrophage accumulation during tissue injury.
Databáze: OpenAIRE
Externí odkaz: