Sesquiterpenoids from the leaves of Sarcandra glabra

Autor:	Luo Jun, Wang Yong-Yue, Chi Jun, Kong Ling-yi, LI Ji-Xin, LI Qiu-Rong
Rok vydání:	2022
Předmět:	Plant Leaves Polycyclic Sesquiterpenes Molecular Structure Complementary and alternative medicine Traditional medicine Chemistry Seeds Drug Discovery Ic50 values General Medicine Sesquiterpenes Sarcandra glabra
Zdroj:	Chinese Journal of Natural Medicines. 20:215-220
ISSN:	1875-5364
DOI:	10.1016/s1875-5364(21)60102-4
Popis:	Sarglanoids A–F, six new sesquiterpenoids belonging to eudesmane ( 1 – 5 ) and eremophilane ( 6 ) types, were isolated from the leaves of Sarcandra glabra, a famous traditional Chinese medicine (TCM). Their structures including absolute configurations were elucidated through extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Thereinto, compounds 1 – 2 were rare N-containing eudesmane-type sesquiterpenoids. Compound 3 exhibited inhibitory activity against nitric oxide (NO) production in lipopolysaccharides (LPS)-induced RAW 264.7 cells with IC50 values at 20.00 ± 1.30 μM. This research provides scientific basis for sesquiterpenoids as the medicinal material foundation of S. glabra.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8463cca33fc5069915f1b3e0d12e249f https://doi.org/10.1016/s1875-5364(21)60102-4 Zobrazit plný text záznamu Full Text from ScienceDirect