Regulatory IgDhi B Cells Suppress T cell Function via IL-10 and PD-L1 During Progressive Visceral Leishmaniasis
| Autor: | Robert G. Schaut, Angela J. Toepp, Mary E. Wilson, John T. Harty, Thomas J. Waldschmidt, Benjamin Scott, Selma M. B. Jeronimo, Ian M. Lamb, José F. V. Coutinho, Christine A. Petersen, Carolina de O. Mendes-Aguiar |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Regulatory B cells T cell Immunology Population Protozoan Proteins Antibodies Protozoan chemical and pharmacologic phenomena Antigens Protozoan Immunoglobulin D CD19 Article B7-H1 Antigen 03 medical and health sciences 0302 clinical medicine Dogs hemic and lymphatic diseases medicine Immune Tolerance Immunology and Allergy Animals Humans Leishmania infantum education Antibodies Blocking Cells Cultured education.field_of_study B-Lymphocytes Regulatory biology business.industry hemic and immune systems Th1 Cells Interleukin-10 Interleukin 10 030104 developmental biology medicine.anatomical_structure CD1D biology.protein Disease Progression Leishmaniasis Visceral Female CD5 business 030215 immunology |
| Popis: | During visceral leishmaniasis (VL), Th1-based inflammation is induced to control intracellular parasites. Inflammation-based pathology was shown to be dampened by IL-10 and eventual programmed death 1–mediated T cell exhaustion. Cell type(s) responsible for the initiation of T cell–produced IL-10 during VL are unknown. CD19+, CD5−, CD1d−, IgDhi regulatory B cells from healthy controls produced IL-10 in the absence of infection or stimulation, in contrast to IgDlo/neg B cells. IgDhi B cells may have a de novo versus induced regulatory program. The population of IgDhi B cells increased 3-fold as VL progressed. B cells from VL dogs were necessary and sufficient to suppress Th1 cell effector function. IgDhi B cells induced IL-10 production by T cells and IgDlo B cells. Blockage of B cell–specific PD-L1 restored Th1 responses. IgDhi regulatory B cells represent a novel regulatory B cell that may precipitate T cell exhaustion during VL. |
| Databáze: | OpenAIRE |
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