Characteristics of vulvar squamous cell carcinoma in Japanese women
| Autor: | Masahiro Hayashi, Yousei Katayama, Iwao Emura, Mitsumasa Osakabe, Keiichi Nemoto, Ken Saitoh, Hajime Umezu, Teiichi Motoyama |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Vulvar Squamous Cell Carcinoma Cell Loss of Heterozygosity Gene mutation Pathology and Forensic Medicine Vulva Loss of heterozygosity Immunoenzyme Techniques Japan medicine Biomarkers Tumor Humans Papillomaviridae Gene Cyclin-Dependent Kinase Inhibitor p16 Aged Vulvar neoplasm Aged 80 and over integumentary system biology Vulvar Neoplasms business.industry Papillomavirus Infections General Medicine DNA Neoplasm Middle Aged biology.organism_classification female genital diseases and pregnancy complications medicine.anatomical_structure DNA Viral Carcinoma Squamous Cell Female Tumor Suppressor Protein p53 business |
| Zdroj: | Pathology international. 57(6) |
| ISSN: | 1320-5463 |
| Popis: | Although the presence of racial differences in vulvar squamous cell carcinomas has been suggested, fully analyzed data concerning such tumors in Japanese women have not been reported. A total of 21 vulvar squamous cell carcinomas of Japanese women who lived in north-east Japan, were studied with respect to histological subtype, HPV, p53 and p16(INK4a). The majority of tumors consisted of keratinizing and non-keratinizing types (16/21, 76%), all of which were negative for HPV. The remaining five tumors of basaloid, warty or verrucous types were positive for HPV. HPV-negative tumors showed a trend of greater accumulation of gene abnormalities, including p53 gene mutation, than HPV-positive ones. p16(INK4a) overexpression was shown to not always be a marker for vulvar squamous cell carcinoma in Japanese women with activated high-risk HPV. |
| Databáze: | OpenAIRE |
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