Invasive atypical thymic carcinoid: three case reports and literature review
| Autor: | Zhong-Tang Wang, Baosheng Li, Wenzhi Liu, Shi-Xiang Zong, Shan Zhu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
carcinoid
Pathology medicine.medical_specialty medicine.medical_treatment Disease 030204 cardiovascular system & hematology OncoTargets and Therapy atypical carcinoid thymic tumors atypical thymic carcinoid 03 medical and health sciences 0302 clinical medicine medicine Pharmacology (medical) Case Series Medical diagnosis Pathological Chemotherapy business.industry Thymic Carcinoid Thyroid medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Immunohistochemistry business Atypical carcinoid neuroendocrine tumor |
| Zdroj: | OncoTargets and therapy |
| ISSN: | 1178-6930 |
| Popis: | Shan Zhu,1,2 Zhong-Tang Wang,2 Wen-Zhi Liu,2,3 Shi-Xiang Zong,4 Bao-Sheng Li2 1School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, 2Department of Radiotherapy, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, 3Department of Clinical Oncology, Taian Central Hospital, Taian, 4Jinan Hospital, Jinan, Shandong Province, People’s Republic of China Abstract: Atypical thymic carcinoid is an extremely rare thymic neuroendocrine tumor derived from the neuroendocrine system. The aims of this paper were to investigate the clinical features of atypical thymic carcinoid and collate information and experience to improve the diagnosis and treatment of this disease. We describe three cases of atypical carcinoid of the thymus; clinical features, pathological data, treatment modalities, and short-term patient outcomes were summarized and analyzed. The initial clinical symptoms and signs of all three patients were nonspecific and an anterior mediastinal mass was found in each patient on chest computed tomography scan. All three patients underwent surgical resection (total thymectomy and complete excision of the tumor), followed by postoperative radiotherapy, with or without chemotherapy. The diagnoses of three patients were confirmed by pathological and immunohistochemical evaluation. We also present a review of the literature to collate as much information as possible and provide a reference for proper diagnosis and treatment of atypical thyroid carcinoid. Keywords: thymic tumors, neuroendocrine tumor, carcinoid, atypical carcinoid, atypical thymic carcinoid |
| Databáze: | OpenAIRE |
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