| Autor: |
Paul Petrus, Jacob G. Smith, Kevin B. Koronowski, Siwei Chen, Tomoki Sato, Carolina M. Greco, Thomas Mortimer, Patrick-Simon Welz, Valentina M. Zinna, Kohei Shimaji, Marlene Cervantes, Daniela Punzo, Pierre Baldi, Pura Muñoz-Cánoves, Paolo Sassone-Corsi, Salvador Aznar Benitah |
| Přispěvatelé: |
Wenner-Gren Foundation, Foundation Blanceflor Boncompagni Ludovisi, Tore Nilsson Foundation for Medical Science, National Institutes of Health (Estados Unidos), Institut National de la Santé et de la Recherche Médicale (Francia), Unión Europea. Comisión Europea. European Research Council (ERC), Unión Europea. Comisión Europea. H2020, Government of Catalonia (España), Ministerio de Economía, Innovación y Competitividad (España), Fundación La Marató TV3, Foundation Lilliane Bettencourt, Asociación Española Contra el Cáncer, Worldwide Cancer Research Foundation, Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España), Marie Curie, American Heart Association, UCI School of Medicine Behrens Research Excellence Award |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Science advances, vol 8, iss 26 |
| Popis: |
Life on Earth anticipates recurring 24-hour environmental cycles via genetically encoded molecular clocks active in all mammalian organs. Communication between these clocks controls circadian homeostasis. Intertissue communication is mediated, in part, by temporal coordination of metabolism. Here, we characterize the extent to which clocks in different organs control systemic metabolic rhythms, an area that remains largely unexplored. We analyzed the metabolome of serum from mice with tissue-specific expression of the clock gene Bmal1. Having functional hepatic and muscle clocks can only drive a minority (13%) of systemic metabolic rhythms. Conversely, limiting Bmal1 expression to the central pacemaker in the brain restores rhythms to 57% of circulatory metabolites. Rhythmic feeding imposed on clockless mice resulted in a similar rescue, indicating that the central clock mainly regulates metabolic rhythms via behavior. These findings explicate the circadian communication between tissues and highlight the importance of the central clock in governing those signals. P.P. was funded by the Wenner-Gren Foundation; the Foundation Blanceflor Boncompagni Ludovisi, née Bildt; and the Tore Nilsson Foundation for Medical Science. Funding for P.S.-C. was provided by the National Institutes of Health (NIH) (AG053592 and DK114652), a Novo Nordisk Foundation Challenge Grant, and Institut National de la Sante et la Recherche Medicale (U1233 INSERM, France). Research in the S.A.B. laboratory is supported partially by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 787041), the Government of Cataluña (SGR grant), the Government of Spain (MINECO), the La Marató/TV3 Foundation, the Foundation Lilliane Bettencourt, the Spanish Association for Cancer Research (AECC), and the Worldwide Cancer Research Foundation (WCRF). The IRB Barcelona is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). P.M.C. acknowledges funding from MICINN-RTI2018-096068, ERC-2016-AdG-741966, LaCaixa-HEALTH-HR17-00040, MDA, UPGRADE-H2020-825825, AFM, DPP-Spain, Fundació La Marató TV3-80/19-202021, MWRF, María-de-Maeztu Program for Units of Excellence to UPF (MDM-2014-0370), and the Severo- Ochoa Program for Centers of Excellence to CNIC (SEV-2015-0505). T.S. was supported by a Japan Society for the Promotion of Science (JSPS) fellowship. C.M.G. was funded by European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 749869. T.M. received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 754510. P.-S.W. is supported by grant RYC2019-026661-I funded by MCIN/ AEI/10.13039/501100011033 and by “ESF Investing in your future.” We acknowledge predoctoral fellowships to M.C. from the NIH (GM117942), the American Heart Association (17PRE33410952), and the UCI School of Medicine Behrens Research Excellence Award. The work of S.C. and P.B. was, in part, supported by NIH grant NIH GM123558. Sí |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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