Case Series of Multisystem Inflammatory Syndrome in Adults Associated with SARS-CoV-2 Infection — United Kingdom and United States, March–August 2020
| Autor: | Lilian M. Abbo, Shuba Balan, Julie Hand, Sapna Bamrah Morris, Ermias D. Belay, Daniel P. Eiras, Sharon E. Fox, Emer Smith, Aaron Kofman, Vennus Ballen, Zachary Ende, Marie Dorsinville, Bobbi Bryant, Pragna Patel, Rachel Paneth-Pollak, Gillian Richardson, Ellen H. Lee, Anita Geevarughese, Noah G. Schwartz, Sarah Lim, Maura K. Lash, Nora T. Oliver, Shana Godfred-Cato, Patricia Stogsdill, Christopher Newton-Cheh, Laura Beauchamps, Deblina Datta, Sara Robinson |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Abdominal pain Health (social science) Epidemiology Health Toxicology and Mutagenesis Pneumonia Viral 01 natural sciences Virus Pathogenesis 03 medical and health sciences Young Adult 0302 clinical medicine Health Information Management Internal medicine Pandemic medicine Humans 030212 general & internal medicine Full Report 0101 mathematics Young adult Pandemics biology business.industry 010102 general mathematics COVID-19 General Medicine Middle Aged medicine.disease Systemic Inflammatory Response Syndrome United Kingdom United States Systemic inflammatory response syndrome Pneumonia biology.protein Female medicine.symptom Antibody business Coronavirus Infections |
| Zdroj: | Morbidity and Mortality Weekly Report |
| ISSN: | 1545-861X 0149-2195 |
| Popis: | During the course of the coronavirus disease 2019 (COVID-19) pandemic, reports of a new multisystem inflammatory syndrome in children (MIS-C) have been increasing in Europe and the United States (1-3). Clinical features in children have varied but predominantly include shock, cardiac dysfunction, abdominal pain, and elevated inflammatory markers, including C-reactive protein (CRP), ferritin, D-dimer, and interleukin-6 (1). Since June 2020, several case reports have described a similar syndrome in adults; this review describes in detail nine patients reported to CDC, seven from published case reports, and summarizes the findings in 11 patients described in three case series in peer-reviewed journals (4-6). These 27 patients had cardiovascular, gastrointestinal, dermatologic, and neurologic symptoms without severe respiratory illness and concurrently received positive test results for SARS-CoV-2, the virus that causes COVID-19, by polymerase chain reaction (PCR) or antibody assays indicating recent infection. Reports of these patients highlight the recognition of an illness referred to here as multisystem inflammatory syndrome in adults (MIS-A), the heterogeneity of clinical signs and symptoms, and the role for antibody testing in identifying similar cases among adults. Clinicians and health departments should consider MIS-A in adults with compatible signs and symptoms. These patients might not have positive SARS-CoV-2 PCR or antigen test results, and antibody testing might be needed to confirm previous SARS-CoV-2 infection. Because of the temporal association between MIS-A and SARS-CoV-2 infections, interventions that prevent COVID-19 might prevent MIS-A. Further research is needed to understand the pathogenesis and long-term effects of this newly described condition. |
| Databáze: | OpenAIRE |
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