Cerebrospinal α-synuclein in α-synuclein aggregation disorders: tau/α-synuclein ratio as potential biomarker for dementia with Lewy bodies

Autor: Niels Kruse, Inga Zerr, Nadine Gotzmann, Franc Llorens, Daniela Varges, Karin Gmitterová, Matthias Schmitz, Brit Mollenhauer
Rok vydání: 2016
Předmět:
0301 basic medicine
complications [Lewy Body Disease]
Lewy Body Disease
Male
medicine.medical_specialty
Pathology
Neurology
Movement disorders
animal diseases
Context (language use)
Enzyme-Linked Immunosorbent Assay
tau Proteins
cerebrospinal fluid [Amyloid beta-Peptides]
cerebrospinal fluid [Lewy Body Disease]
Protein Aggregation
Pathological
Statistics
Nonparametric
03 medical and health sciences
0302 clinical medicine
Atrophy
mental disorders
medicine
Dementia
Humans
ddc:610
cerebrospinal fluid [Peptide Fragments]
Aged
Amyloid beta-Peptides
Essential tremor
Dementia with Lewy bodies
amyloid beta-protein (1-40)
Middle Aged
medicine.disease
amyloid beta-protein (1-42)
Peptide Fragments
nervous system diseases
030104 developmental biology
nervous system
cerebrospinal fluid [Biomarkers]
cerebrospinal fluid [tau Proteins]
ROC Curve
Biomarker (medicine)
Female
Neurology (clinical)
medicine.symptom
Psychology
etiology [Protein Aggregation
Pathological]
030217 neurology & neurosurgery
Biomarkers
Zdroj: Journal of neurology 263(11), 2271-2277 (2016). doi:10.1007/s00415-016-8259-0
ISSN: 1432-1459
DOI: 10.1007/s00415-016-8259-0
Popis: Several studies have addressed the utility of cerebrospinal (CSF) α-synuclein levels as a potential biomarker of α-synuclein aggregation disorders. However, its relevance in the differential diagnostic context of neurodegenerative and movement disorders is still a contentious subject. Here, we report total CSF α-synuclein levels in a cohort of clinically diagnosed α-synuclein-related disorders encompassing Parkinson's disease, Parkinson's disease dementia, dementia with Lewy bodies and multiple system atrophy in comparison to essential tremor and neurological control cases. α-synuclein levels in α-synuclein-related disorders were significantly lower than in controls (p
Databáze: OpenAIRE
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