A combination of hepatic encephalopathy and body mass index was associated with the point of no return for improving liver functional reserve after sofosbuvir/velpatasvir treatment in patients with hepatitis C virus‐related decompensated cirrhosis

Autor: Tomoya Sano, Keisuke Amano, Tatsuya Ide, Keiji Yokoyama, Kazunori Noguchi, Hiroki Nakamura, Hiroshi Isoda, Miki Ohno, Miki Shirachi, Yasuyo Morita, Yoichi Yano, Shuji Sumie, Toshihiro Kawaguchi, Reiichiro Kuwahara, Teruko Arinaga‐Hino, Hirokazu Takahashi, Satoshi Shakado, Fumihito Hirai, Takumi Kawaguchi
Rok vydání: 2022
Předmět:
Zdroj: Hepatology Research. 53:26-34
ISSN: 1872-034X
1386-6346
DOI: 10.1111/hepr.13837
Popis: The real-world efficacy of sofosbuvir/velpatasvir treatment for patients with hepatitis C virus-related decompensated cirrhosis is unclear. We aimed to identify factors that improve liver functional reserve after treatment.This was a multicenter retrospective study of 12-week sofosbuvir/velpatasvir treatment. A total of 48 patients with Child-Pugh (CP) class B or C were enrolled at 11 institutions. We evaluated changes in liver functional reserve at 24 weeks post-treatment.At baseline, 40 and eight patients were CP class B and C, respectively. The overall rate of sustained virologic response 12 weeks post-treatment was 95.8% (46/48). Serum albumin, alanine aminotransferase and α-fetoprotein levels, and the FIB-4 index were significantly improved post-treatment (P 0.05). Among patients who achieved sustained virologic response 12 weeks post-treatment, those with CP class A increased from 0 to 24 patients (56%) at 24 weeks post-treatment. In multivariate analysis, body mass index (BMI) ≥25 was an independent factor that inhibited CP class improvement (P 0.05). In decision tree analysis, after treatment, the initial divergent variable for CP class improvement was hepatic encephalopathy, followed by serum sodium level and BMI.Sofosbuvir/velpatasvir treatment improved the liver functional reserve in patients with hepatitis C virus-related decompensated cirrhosis at 24 weeks post-treatment. However, BMI ≥25 inhibited improvement in CP class. Additionally, decision tree analysis revealed that a combination of hepatic encephalopathy, serum sodium levels, and BMI were diversity profiles associated with no improvement in liver functional reserve after the treatment.
Databáze: OpenAIRE
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