Effects of cannabidiol in males and females in two different rat models of depression
| Autor: | Kayla Rapps, Noa Hazut, Aron Weller, Gal Shoval, Raphael Mechoulam, Shira Dar, Gil Zalsman, Danielle Hen-Shoval, Liat Shbiro |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Experimental and Cognitive Psychology Learned helplessness Motor Activity Rats Inbred WKY digestive system Food Preferences 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound Saccharin 0302 clinical medicine Preference test Internal medicine Animal models of depression Genetic model medicine Animals Cannabidiol 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology Swimming Depressive Disorder business.industry 05 social sciences Anhedonia Antidepressive Agents digestive system diseases Rats Disease Models Animal surgical procedures operative Endocrinology chemistry Female medicine.symptom business 030217 neurology & neurosurgery Behavioural despair test medicine.drug |
| Zdroj: | Physiology & Behavior. 201:59-63 |
| ISSN: | 0031-9384 |
| DOI: | 10.1016/j.physbeh.2018.12.019 |
| Popis: | The current study explores the therapeutic potential of Cannabidiol (CBD), a compound in the Cannabis plant, using both sexes of 2 “depressive-like” genetic models, Wistar Kyoto (WKY) and Flinders Sensitive Line (FSL) rats. Rats ingested CBD (30 mg/kg) orally. In the saccharin preference test, following a previous report of a pro-hedonic effect of CBD in male WKY, we now found similar results in female WKY. CBD also decreased immobility in the forced swim test in males (both strains) and in female WKY. These findings suggest a role for CBD in treating mental disorders with prominent symptoms of helplessness and anhedonia. |
| Databáze: | OpenAIRE |
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