Acquired cystic disease-associated renal cell carcinoma: a clinicopathological study of seven cases
| Autor: | Takushi Naroda, Kenji Yorita, Masato Tamura, Naoto Kuroda, Fumiyoshi Kojima, Shin-ichi Murata |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Time Factors Biopsy medicine.medical_treatment Disease 030204 cardiovascular system & hematology Nephrectomy Pathology and Forensic Medicine Metastasis 03 medical and health sciences 0302 clinical medicine Stroma Renal cell carcinoma Eosinophilic Biomarkers Tumor medicine Humans Carcinoma Renal Cell In Situ Hybridization Fluorescence Aged Cystic disease Incidental Findings business.industry Clinical course General Medicine Kidney Diseases Cystic Middle Aged medicine.disease Immunohistochemistry Kidney Neoplasms Treatment Outcome 030220 oncology & carcinogenesis Female Hemodialysis business |
| Zdroj: | Polish Journal of Pathology. 68:306-311 |
| ISSN: | 1233-9687 |
| DOI: | 10.5114/pjp.2017.73926 |
| Popis: | The disease entity of acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) has been recently incorporated into the international renal tumor classification. However, there are a few descriptions on clinicopathologic features. We performed a clinicopathologic study of seven cases with ACD-RCC. All tumors were incidentally found. Histologically, the tumor consisted of microcystic or cribriform pattern of neoplastic cells with deeply eosinophilic to oncocytic cytoplasm in the stroma of oxalate crystal deposition. Three cases contained the area of sarcomatoid transformation, of which one case also demonstrated rhabdoid phenotype foci. Six among seven patients had a hemodialysis history of more than 10 years and two patients showing the dedifferentiation had a hemodialysis history of more than 20 years. The follow-up duration ranged from 18 to 107 months with a mean of 59.1 months. Regarding the outcome, four patients were alive without disease. One patient was alive with metastasis 10 months after the operation. No patient died of disease. Finally, ACD-RCC generally pursues a favorable clinical course, but tumors with a hemodialysis history of more than 20 years may cause the dedifferentiation such as sarcomatoid change or rhabdoid features and this phenomenon may lead to worse clinical outcome. |
| Databáze: | OpenAIRE |
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