Colorectal metastases to the liver: Present results and future strategies
| Autor: | P. P. Da Pian, Donato Nitti, P. Pilati, Mario Lise |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Colorectal cancer Adjuvant chemotherapy medicine.medical_treatment Rectum law.invention Metastasis Randomized controlled trial law Antineoplastic Combined Chemotherapy Protocols medicine Hepatectomy Humans Infusions Intra-Arterial Survival rate Chemotherapy business.industry Liver Neoplasms General Medicine Middle Aged medicine.disease Combined Modality Therapy Surgery Survival Rate Clinical trial medicine.anatomical_structure Oncology Female Fluorouracil Radiology Colorectal Neoplasms Floxuridine business |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1096-9098 0022-4790 |
| Popis: | In recent years, wide agreement has been expressed on the value of surgical resection for liver metastases from colorectal cancer, while for unresectable patients different types of locoregional treatment have been attempted. One hundred seventy-one patients with hepatic metastases from colorectal cancer were treated by us over a period of 15 years. Sixty-four underwent hepatic resection, and 107 underwent various forms of locoregional treatment. Our experience confirms the opinion that hepatic resection can be performed with a "curative" aim in patients with colorectal liver metastases: a 5-year survival rate can be achieved in about 30% of resectable cases. Adjuvant chemotherapy after hepatic resection should be tested in prospective randomized trials. Patients with diffuse liver metastases can benefit from locoregional infusion chemotherapy. Symptoms improve in most patients and objective responses are higher than those reported for systemic chemotherapy. Survival benefit with respect to untreated patients, has not yet been demonstrated by prospective randomized studies. Future improvements may be achieved by using new treatment modalities, such as new drug combinations, repeat arterial ischemia, and local tumor destruction. As these types of treatment are still experimental they should be employed only in prospective clinical trials. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text