Cobalt-catalyzed sequential cyclization/cross-coupling reactions of 6-halo-1-hexene derivatives with Grignard reagents and their application to the synthesis of 1,3-diols
| Autor: | Hidenori Someya, Hirohisa Ohmiya, Hideki Yorimitsu, Koichiro Oshima |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Grignard reagent
Aryl Organic Chemistry chemistry.chemical_element 1 3-diols General Medicine Cobalt Biochemistry Medicinal chemistry Coupling reaction Catalysis 1-Hexene chemistry.chemical_compound 1 3-Diols chemistry Reagent Diamine Drug Discovery N-Heterocyclic carbene Organic chemistry Cross-coupling reaction Carbene |
| Zdroj: | Tetrahedron. 63(35):8609-8618 |
| ISSN: | 0040-4020 |
| Popis: | Cobalt/N-heterocyclic carbene system or cobalt/diamine combination effectively catalyzes sequential cyclization/cross-coupling reactions of 6-halo-1-hexene derivatives with trialkylsilylmethyl, 1-alkynyl, and aryl Grignard reagents. The sequential cyclization/cross-coupling reactions are applied to the synthesis of 1,3-diols starting from siloxy-tethered 6-halo-1-hexene derivatives. |
| Databáze: | OpenAIRE |
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