GLCCI1 rs37973 is associated with the response of adrenal hormone to inhaled corticosteroids in asthma
Autor: | Juntao Feng, Xiao-Zhao Li, Qiufen Xun, Chengping Hu, Xinyue Hu, Ruoxi He, Ling Qin, Rongli Lu |
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Rok vydání: | 2019 |
Předmět: |
lcsh:Immunologic diseases. Allergy
Pulmonary and Respiratory Medicine medicine.medical_specialty medicine.drug_class Immunology Inhaled corticosteroids Article Fluticasone propionate 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Immunology and Allergy Asthmatic patient GLCCI1 030223 otorhinolaryngology Asthma business.industry Human airway medicine.disease Endocrinology Epinephrine 030228 respiratory system Corticosteroid lcsh:RC581-607 business Adrenal hormone medicine.drug Hormone |
Zdroj: | World Allergy Organization Journal, Vol 12, Iss 3, Pp-(2019) The World Allergy Organization Journal |
ISSN: | 1939-4551 |
Popis: | Background: Previous studies have demonstrated that glucocorticoid-induced transcript 1 gene (GLCCI1) rs37973 mutant genotype is associated with poor inhaled corticosteroid (ICS) response in asthmatics. As human airway relaxation is regulated by circulation epinephrine, which can be enhanced by corticosteroid. It is unknown whether or not GLCCI1 rs37973 is associated with circulation epinephrine and cortisol concentrations in asthma. The aim of this study is to evaluate these relationships. Methods: A total of 182 asthmatics and 180 healthy controls were recruited for the study. 30 mild-to-moderate asthmatics received fluticasone propionate (125 μg, bid) treatment for 12 weeks. GLCCI1 rs37973 genotyping was performed with the iPlex MassARRAY genotyping platform. The plasma concentrations of cortisol and epinephrine of each participant were detected by enzyme linked immunosorbent assay (ELISA) kits. Results: GLCCI1 rs37973 homozygotes mutant genotype GG had a higher plasma epinephrine concentration (median concentration 27.032 pg/ml, nGG = 36; median concentration 23.149 pg/ml, nAA+AG = 146; P = 0.015) and cortisol concentration (median concentration 1.141 ng/ml, nGG = 36; median concentration 0.921 ng/ml, nAA+AG = 146; P = 0.013). Both epinephrine concentration and cortisol concentration in plasma were positively correlated with FEV1 (r = 0.889 and r = 0.821, respectively. nasthma = 182). For asthmatics treated with ICS, rs37973 was associated with change in plasma epinephrine and cortisol concentration in a recessive model (AA + AG vs GG), with GG had less improvement in epinephrine concentration [ΔEPIAA+AG = 6.843 (9.26) pg/ml, nAA+AG = 26; ΔEPIGG = −1.666 (6.52) pg/ml, nGG = 4; P = 0.018] and cortisol concentration [ΔCORAA+AG = 0.3040 (0.21) ng/ml, nAA+AG = 26; ΔCORGG = −0.066 (0.24) ng/ml, nGG = 4; P = 0.009]. Conclusions: Our study suggested that the poor ICS response in GLCCI1 rs37973 mutant genotype might be related to the less increased amplitudes of plasma epinephrine and cortisol in asthmatic patients. Trial registration: ChiCTR-RCC-13003634 www.chictr.org.cn. Active since September 27, 2013. Keywords: GLCCI1, Adrenal hormone, Inhaled corticosteroids, Asthma |
Databáze: | OpenAIRE |
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