Seizure Induced by a Therapeutic Dose of Venlafaxine ER: A Case Report
Autor: | Chuanzhong Ye, Fanglin Zhang, Megan Ninneman, Judd S Christian, Dominique Musselman |
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Rok vydání: | 2018 |
Předmět: |
Adult
Depressive Disorder Major business.industry Venlafaxine Hydrochloride Venlafaxine Drug interaction Lamotrigine 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Therapeutic index Norepinephrine reuptake inhibitor Seizures Levofloxacin Delayed-Action Preparations Anesthesia medicine Humans Female Dosing Serotonin and Noradrenaline Reuptake Inhibitors Adverse effect business 030217 neurology & neurosurgery medicine.drug |
Zdroj: | Journal of Psychiatric Practice. 24:117-120 |
ISSN: | 1538-1145 |
Popis: | Venlafaxine is a selective serotonin and norepinephrine reuptake inhibitor commonly used for the treatment of depression. Although listed as an adverse reaction, seizure activity associated with a therapeutic dose of venlafaxine has rarely been documented. A review of the literature reveals only 2 cases of venlafaxine-induced seizures, both of which were generalized tonic-clonic seizures in patients on doses at the higher end of the therapeutic range. We report the case of a 44-year-old woman undergoing antituberculosis therapy who suffered complex partial seizures after ingestion of a low therapeutic dose of venlafaxine extended release (ER). Her first seizure was observed soon after venlafaxine ER was titrated from 37.5 to 75 mg daily, with a total of 9 witnessed complex partial seizures. After titrating the dose of the venlafaxine ER back down to 37.5 mg daily and beginning lamotrigine anticonvulsant therapy, the patient exhibited no further seizures. The development of seizure activity under therapeutic dosing of venlafaxine should be brought to the attention of the health care prescriber. The potential for drug-drug interactions involving venlafazine, particularly in combination with multiple drugs, such as isoniazid and levofloxacin, needs to be recognized. |
Databáze: | OpenAIRE |
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