Cortical sources of EEG rhythms in congestive heart failure and Alzheimer's disease
| Autor: | Giovanni B. Frisoni, Maria Gabriella Scarpellini, Paola Buffo, Fabrizio Vecchio, Lavinia Valeriani, Oriano Mecarelli, Claudio Babiloni, Paolo Maria Rossini |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Pilot Projects Neuropsychological Tests Electroencephalography Rhythm Alzheimer Disease Physiology (medical) Natriuretic Peptide Brain Image Processing Computer-Assisted medicine Humans Dementia Aged Aged 80 and over Cerebral Cortex Heart Failure Mini–Mental State Examination medicine.diagnostic_test General Neuroscience Neurodegeneration Hypoxia (medical) medicine.disease Brain natriuretic peptide Magnetic Resonance Imaging Settore MED/26 - NEUROLOGIA Neuropsychology and Physiological Psychology cortical sources Congestive heart failure (CHF) Cognitive impairment Electroencephalography (EEG) B-type natriuretic peptide (BNP) Alzheimer's disease (AD) Dementia LORETA Heart failure Educational Status Female medicine.symptom Cognition Disorders Psychology Neuroscience |
| Popis: | Introduction The brain needs continuous oxygen supply even in resting-state. Hypoxia enhances resting-state electroencephalographic (EEG) rhythms in the delta range, and reduces those in the alpha range, with a pattern similar to that observed in Alzheimer's disease (AD). Here we tested whether resting-state cortical EEG rhythms in patients with congestive heart failure (CHF), as a model of acute hypoxia, present frequency similarities with AD patients, comparable by cognitive status revealed by the mini mental state examination (MMSE). Methods Eyes-closed EEG data were recorded in 10 CHF patients, 20 AD patients, and 20 healthy elderly subjects (Nold) as controls. LORETA software estimated cortical EEG generators. Results Compared to Nold, both AD and CHF groups presented higher delta (2–4 Hz) and lower alpha (8–13 Hz) temporal sources. The highest delta and lowest alpha sources were observed in CHF subjects. In these subjects, the global amplitude of delta sources correlated with brain natriuretic peptide (BNP) level in the blood, as a marker of disease severity. Conclusions Resting-state delta and alpha rhythms suggest analogies between the effects of acute hypoxia and AD neurodegeneration on the cortical neurons' synchronization. Significance Acute ischemic hypoxia could affect the mechanisms of cortical neural synchronization generating resting state EEG rhythms, inducing the “slowing” of EEG rhythms typically observed in AD patients. |
| Databáze: | OpenAIRE |
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