Comparative characteristics of individuals with high normal blood pressure according to the carotid intima-media values
| Autor: | V. A. Tchernetsov, E. V. Kryukov, Fursov An, T. G. Makeeva, E G Zakharova, K A Sarkisov, Potekhin Np |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Ambulatory blood pressure medicine.diagnostic_test business.industry Physical examination medicine.disease Surgery Blood pressure Intima-media thickness Internal medicine Blood plasma cardiovascular system medicine Arterial stiffness Cardiology Internal Medicine cardiovascular diseases business Ventricular remodeling Cardiology and Cardiovascular Medicine Electrocardiography |
| Zdroj: | "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 22:41-50 |
| ISSN: | 2411-8524 1607-419X |
| DOI: | 10.18705/1607-419x-2016-1-1- |
| Popis: | Objective. Based on factor analysis, we identified the most clinically significant characteristics of subjects with high normal blood pressure (BP) depending on the values of carotid intima-media thickness (IMT). Design and methods. Altogether 88 patients (60 men and 28 women) with high-normal BP (Russian Society of Cardiology, 2010) were examined (mean age — 34,1±2,7 years, duration of history of high-normal BP was 4,4±1,3 years). They were divided into 2 groups: 1st included 45 individuals with IMT < 0,9 mm, the 2nd group consisted of 43 subjects with IMT ≥ 0,9 mm. All subjects underwent clinical examination, clinical and biochemical blood tests, electrocardiography (ECG), echocardiography, veloergometry, ambulatory blood pressure monitoring (ABPM) with central BP and arterial stiffness assessment, ECG monitoring, duplex scan of carotid IMT. Blood plasma levels of some hormones were also assessed. Results. Factor analysis showed that BP is not related to other traditional risk factors in the group 1, while it is the leading factor in the 2nd group. Cardio-renal relations are present even when IMT is within normal values. Group 2 is characterized by BP-associated vascular remodeling, and left ventricular remodeling. The structural and functional changes were independent from lipid levels. Vascular stiffness correlated with changes in BP circadian rhythm. Increased IMT is associated with «non-dipper» daily BP pattern. Conclusions. IMT increase in individuals with high normal BP may identify the risk of the transition from functional to organic vascular changes, followed by hypertension occurrence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|