Platinum(II)-azoimidazole drugs against TB and cancer: Structural studies, cytotoxicity and anti-mycobacterial activity
Autor: | Chandana Sen, Pinar Celikboyun, Tulin Askun, Sudipa Mondol, Chittaranjan Sinha, Chiranjit Patra, Tapan Kumar Mondal, Amitabha Datta, Zerrin Cantürk, Debashis Mallick |
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Přispěvatelé: | Anadolu Üniversitesi, Eczacılık Fakültesi, Mikrobiyoloji Anabilim Dalı |
Rok vydání: | 2018 |
Předmět: |
Stereochemistry
Cytotoxicity 010402 general chemistry 010403 inorganic & nuclear chemistry 01 natural sciences Inorganic Chemistry Mycobacterium tuberculosis Dna Interaction Materials Chemistry medicine Cytotoxic T cell Physical and Theoretical Chemistry Fibroblast biology Platinum(Ii)-Arylazoimidazoles Chemistry Cancer X-Ray Structure biology.organism_classification medicine.disease Binding constant In vitro 0104 chemical sciences Antibacterial Activity medicine.anatomical_structure Antibacterial activity |
Zdroj: | Polyhedron. 152:1-10 |
ISSN: | 0277-5387 |
Popis: | WOS: 000441856400001 1-Alkyl-2-(arylazo)imidazoles (Haai-C4H9 (1), Haai-C10H21 (2)) and their Pt(II) complexes, [Pt(Haai-C4H9)Cl-2] (3) and [Pt(Haai-C10H21)Cl-2] (4) were synthesized and characterized by different spectroscopic studies and structural confirmation has been achieved in the case of complex 3 by single crystal X-ray diffraction analysis. Complexes 3 and 4 were evaluated for their in vitro anti-mycobacterial activity against Mycobacterium tuberculosis H37Ra (ATCC 25177) and H(37)Rv (ATCC 25618) strains, as well as against two clinical strains. Their cytotoxic effects on three cancer cell lines, A549 (human lung carcinoma), MCF-7 (human breast cancer) and Caco-2 (colorectal adenocarcinoma line), and one normal cell line, 3T3 (mouse normal fibroblast) were examined. The DNA interaction of the complexes shows that the intrinsic binding constant (K-b) decreases with the increasing molecular dimension and the chain length of the 1-alkyl group. The longer 1-alkyl chain substituted complex, [Pt(Haai-C10H21)Cl-2] (4), is less efficient due to hydrophobic interactions than the lower homologue [Pt(Haai-C4H9)Cl-2] (3) (K-b(3), 5.9(2) x 10(6) M-1 and molar volume, 276.03(10) cm(3) mol(-1); [Pt(Haai-C10H21)Cl-2], K-b(4), 5.86(2) x 10(5) M-1 and molar volume, 397.56(8) cm(3) mol(-1)) University Grants Commission, New Delhi, India [F./PDFSS-2015-17-WES-12882]; Council of Scientific and Industrial Research (CSIR), New Delhi, India [01(2731)/13/EMR-II] Financial support from the University Grants Commission (No. F./PDFSS-2015-17-WES-12882) New Delhi, India and the Council of Scientific and Industrial Research (CSIR, Sanction No. 01(2731)/13/EMR-II,), New Delhi, India are gratefully acknowledged. |
Databáze: | OpenAIRE |
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