n-3 PUFAs improve erythrocyte fatty acid profile in patients with small AAA: a randomized controlled trial
| Autor: | Maria Perissiou, Pankaj Jha, Mark Windsor, Karl Schulze, Fraser D. Russell, Peter Brooks, Rebecca Magee, Tom G. Bailey, Jill O'Donnell, Jonathan Golledge, Rebecca M.L. Ramirez Jewell, Peter Young, Lara T. Meital, Christopher D. Askew |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Erythrocytes Fatty Acid Elongases Linoleic acid Inflammation QD415-436 030204 cardiovascular system & hematology Biochemistry Gas Chromatography-Mass Spectrometry Linoleic Acid 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Internal medicine Fatty Acids Omega-3 medicine Humans clinical studies Aged Cause of death chemistry.chemical_classification abdominal aortic aneurysms omega-3 fatty acids business.industry Fatty Acids Fatty acid Red blood cell distribution width Cell Biology Middle Aged Lipid Metabolism medicine.disease Abdominal aortic aneurysm antioxidants 030104 developmental biology chemistry Fatty Acids Unsaturated Female Arachidonic acid diet and dietary lipids medicine.symptom Patient-Oriented and Epidemiological Research business diet effects/lipid metabolism Aortic Aneurysm Abdominal Polyunsaturated fatty acid |
| Zdroj: | Journal of Lipid Research, Vol 60, Iss 6, Pp 1154-1163 (2019) J Lipid Res |
| ISSN: | 0022-2275 |
| Popis: | Abdominal aortic aneurysm (AAA) is an important cause of death in older adults, which has no current drug therapy. Inflammation and abnormal redox status are believed to be key pathogenic mechanisms for AAA. In light of evidence correlating inflammation with aberrant fatty acid profiles, this study compared erythrocyte fatty acid content in 43 AAA patients (diameter 3.0–4.5 cm) and 52 healthy controls. In addition, the effect of omega-3 PUFA (n-3 PUFA) supplementation on erythrocyte fatty acid content was examined in a cohort of 30 AAA patients as part of a 12 week randomized placebo-controlled clinical trial. Blood analyses identified associations between AAA and decreased linoleic acid (LA), and AAA and increased Δ6-desaturase activity and biosynthesis of arachidonic acid (AA) from LA. Omega-3 PUFA supplementation (1.5 g DHA + 0.3 g EPA/day) decreased red blood cell distribution width (14.8 ± 0.4% to 13.8 ± 0.2%; P = 0.003) and levels of pro-inflammatory n-6 PUFAs (AA, 12.46 ± 0.23% to 10.14 ± 0.3%, P < 0.001; adrenic acid, 2.12 ± 0.13% to 1.23 ± 0.09%; P < 0.001). In addition, Δ-4 desaturase activity increased (DHA/docosapentaenoic acid ratio, 1.85 ± 0.14 to 3.93 ± 0.17; P < 0.001) and elongase 2/5 activity decreased (adrenic acid/AA ratio, 0.17 ± 0.01 to 0.12 ± 0.01; P < 0.01) following supplementation. The findings suggest that n-3 PUFAs improve fatty acid profiles and ameliorate factors associated with inflammation in AAA patients. |
| Databáze: | OpenAIRE |
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