Update on the role of p75NTR in neurological disorders: A novel therapeutic target
| Autor: | Xiu-Min Lu, Lan Xiao, Ya-Hai Shu, Yong-Tang Wang, Jing-Xiang Wei |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Cell Survival Apoptosis Neurological disorder Disease Receptor Nerve Growth Factor Cell Movement Neurotrophic factors medicine Animals Humans Low-affinity nerve growth factor receptor Amyotrophic lateral sclerosis Psychiatry Pharmacology Mechanism (biology) business.industry Mental Disorders Cell Cycle Checkpoints General Medicine medicine.disease Schizophrenia Major depressive disorder sense organs Nervous System Diseases business Neuroscience |
| Zdroj: | Biomedicine & Pharmacotherapy. 76:17-23 |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/j.biopha.2015.10.010 |
| Popis: | As a low-affinity neurotrophins receptor, p75 neurotrophin receptor (p75NTR) is a transmembrane receptor involved in a diverse array of cellular responses, including apoptosis, survival, neurite outgrowth, migration, and cell cycle arrest, which may be related to some neurological disorders, such as Alzheimer's disease (AD), schizophrenia, major depressive disorder (MDD), posttraumatic stress disorder (PTSD), amyotrophic lateral sclerosis (ALS), and Parkinson's disease (PD). Indeed, a series of studies during the last decade has demonstrated that the p75NTR signaling plays key roles in most aspects of the neurological disorder diseases. In spite of the limited information available, this review still tried to summary the relationship between p75NTR and diverse neurological disorder diseases, and tried to further clarify the possible mechanism, which may provide a novel therapeutic target for the treatment of neurological disorders. |
| Databáze: | OpenAIRE |
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