MiR‐497‐5p inhibits cell proliferation and metastasis in hepatocellular carcinoma by targeting insulin‐like growth factor 1
| Autor: | Hai-Jian Zou, Zhi-Ping Huang, F. Charles Brunicardi, Jia Fu, Chao Song, Guo-Shu Xu, Zi-Wei Li, Rui-Fen Sun |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_treatment Apoptosis 030105 genetics & heredity medicine.disease_cause Metastasis Mice Cell Movement Insulin-Like Growth Factor I Neoplasm Metastasis 3' Untranslated Regions Genetics (clinical) Liver Neoplasms IGF1 hepatocellular carcinoma Middle Aged Prognosis 3. Good health Hepatocellular carcinoma biomarker Original Article Female Carcinoma Hepatocellular lcsh:QH426-470 proliferation Down-Regulation Mice Nude 03 medical and health sciences Downregulation and upregulation miR‐497‐5p Cell Line Tumor microRNA Genetics medicine Animals Humans Molecular Biology neoplasms Cell Proliferation Cell growth business.industry Growth factor Cancer Antagomirs Original Articles medicine.disease digestive system diseases MicroRNAs lcsh:Genetics 030104 developmental biology Cancer research Carcinogenesis business |
| Zdroj: | Molecular Genetics & Genomic Medicine, Vol 7, Iss 10, Pp n/a-n/a (2019) Molecular Genetics & Genomic Medicine |
| ISSN: | 2324-9269 |
| Popis: | Background MicroRNAs (miRNAs) play an important regulatory role in carcinogenesis and cancer progression. Aberrant expression of miR‐497‐5p has been reported in various human malignancies. However, the role of miR‐497‐5p in hepatocellular carcinoma (HCC) remains unclear. Results In this study, we found that miR‐497‐5p was downregulated in HCC tissues. The low level of miR‐497‐5p in HCC tumors was correlated with aggressive clinicopathological characteristics and predicted poor prognosis in HCC patients. The overexpression of miR‐497‐5p significantly inhibited HCC cell proliferation, colony formation, and metastasis in vitro and vivo. Bioinformatics analysis further identified insulin‐like growth factor 1 (IGF1) as a novel target of miR‐497‐5p in HCC cells. Conclusion Our study suggested that miR‐497‐5p regulates HCC cell survival, partially through downregulation of IGF1. Therefore, the miR‐497‐5p/IGF1 axis might serve as a novel therapeutic target in patients with HCC. |
| Databáze: | OpenAIRE |
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