Microbiome manipulation by a soil-borne fungal plant pathogen using effector proteins
| Autor: | Gabriella C. Petti, Bart P. H. J. Thomma, Mercedes Rocafort, Michael F. Seidl, Grardy C. M. van den Berg, Reindert Nijland, Julia A. Vorholt, Nick C. Snelders, Hanna Rovenich, Jeroen R. Mesters |
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| Přispěvatelé: | Sub Bioinformatics, Theoretical Biology and Bioinformatics |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
0301 basic medicine Virulence Plant Science Fungus 01 natural sciences Plant Roots Microbiology Fungal Proteins 03 medical and health sciences Microbial ecology Ascomycota Solanum lycopersicum Xylem Life Science Verticillium dahliae Microbiome Pathogen Soil Microbiology Plant Diseases Gossypium biology Host (biology) Effector Microbiota biology.organism_classification Laboratorium voor Phytopathologie 030104 developmental biology Laboratory of Phytopathology Microscopy Electron Scanning EPS Transcriptome 010606 plant biology & botany |
| Zdroj: | Nature Plants, 6, 1365-1374 Nature Plants, 6(11), 1365. Palgrave Macmillan Ltd. Nature Plants 6 (2020) |
| ISSN: | 1365-1374 2055-026X |
| Popis: | During colonization of their hosts, pathogens secrete effector proteins to promote disease development through various mechanisms. Increasing evidence shows that the host microbiome plays a crucial role in health, and that hosts actively shape their microbiomes to suppress disease. We proposed that pathogens evolved to manipulate host microbiomes to their advantage in turn. Here, we show that the previously identified virulence effector VdAve1, secreted by the fungal plant pathogen Verticillium dahliae, displays antimicrobial activity and facilitates colonization of tomato and cotton through the manipulation of their microbiomes by suppressing antagonistic bacteria. Moreover, we show that VdAve1, and also the newly identified antimicrobial effector VdAMP2, are exploited for microbiome manipulation in the soil environment, where the fungus resides in absence of a host. In conclusion, we demonstrate that a fungal plant pathogen uses effector proteins to modulate microbiome compositions inside and outside the host, and propose that pathogen effector catalogues represent an untapped resource for new antibiotics. |
| Databáze: | OpenAIRE |
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