Medium-sized FLT3 internal tandem duplications confer worse prognosis than short and long duplications in a non-elderly acute myeloid leukemia cohort
| Autor: | Otto Csacsovszki, Nóra Lovas, Eniko Lehoczky, András Kozma, Péter Reményi, Tunde Krahling, Attila Tordai, Magdalena Koszarska, András Bors, Tamas Masszi, Emma Ádám, Sándor Fekete, Hajnalka Andrikovics, Nóra Meggyesi, Árpád Bátai, János Dolgos, Andrea Sipos |
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| Rok vydání: | 2013 |
| Předmět: |
Oncology
FLT3 Internal Tandem Duplication Adult Male Cancer Research medicine.medical_specialty Multivariate analysis Adolescent Genotype Biology Bioinformatics medicine.disease_cause Young Adult hemic and lymphatic diseases Molecular genetics Internal medicine Gene Duplication Antineoplastic Combined Chemotherapy Protocols medicine Humans Mutation Wild type Hematopoietic Stem Cell Transplantation Myeloid leukemia hemic and immune systems Adult Acute Myeloid Leukemia Hematology Middle Aged Prognosis body regions Leukemia Myeloid Acute Treatment Outcome fms-Like Tyrosine Kinase 3 Tandem Repeat Sequences embryonic structures Cohort Female psychological phenomena and processes |
| Zdroj: | Leukemialymphoma. 55(7) |
| ISSN: | 1029-2403 |
| Popis: | Internal tandem duplications (ITDs) of the fms-like tyrosine kinase 3 (FLT3) gene occur in about 25% of patients with adult acute myeloid leukemia (AML). The aim of our study was to investigate the frequency of FLT3-ITD mutations followed by a detailed analysis of the mutational load and size of ITD insertions in a cohort consisting of 324 patients younger than 60 years old and treated with curative intention. FLT3-ITD alone did not influence overall survival (OS) or disease-free survival (DFS). We observed worse OS and DFS for patients with high mutational load indicative for loss of the FLT3 wild type allele (p = 0.010, p = 0.038, respectively). In multivariate analyses, patients with FLT3-ITD(48-60bp) showed worse OS and DFS compared to other groups (FLT3-ITD(neg), FLT3-ITD (48b), FLT3-ITD (60bp); p = 0.014, p = 0.019, respectively). Our novel observation suggested that not only high FLT3-ITD load, but also medium-sized ITD insertions (48-60 bp) represented an adverse prognostic subgroup of patients with AML. |
| Databáze: | OpenAIRE |
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