Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts
| Autor: | Alison D. Murray, Anna L. Guyatt, Jing Hua Zhao, Eugene R. Bleecker, Matthias Wielscher, Frank Dudbridge, Martin D. Tobin, Veronique Vitart, Ida Surakka, Nadia N. Hansel, Ozren Polasek, Caroline Hayward, David P. Strachan, Per Bakke, Stefan Karrasch, Anubha Mahajan, James F. Wilson, Shona M. Kerr, Ruth Tal-Singer, James D. Crapo, Victoria E. Jackson, Jonathan Marten, Olli T. Raitakari, María Soler Artigas, Medea Imboden, Sungho Won, Beate Stubbe, Ulf Gyllensten, George R. Washko, Eleftheria Zeggini, David A. Lynch, Brian D. Hobbs, Matthew Moll, Mika Kähönen, Rajesh Rawal, Guy Brusselle, Ma'en Obeidat, Nicholas J. Wareham, Claudia Langenberg, Nicole Probst-Hensch, Peter K. Joshi, Blair H. Smith, Stefan Weiss, Woo Jin Kim, Kathleen C. Barnes, Sarah E. Harris, David J. Porteous, Stefan Enroth, Ian P. Hall, Alan L. James, Sina A. Gharib, Paul R. H. J. Timmers, Xingnan Li, Louise V. Wain, John E. Hokanson, Holger Schulz, Ralf Ewert, Ani Manichaikul, Lies Lahousse, Georg Homuth, R. Graham Barr, Scott T. Weiss, Phuwanat Sakornsakolpat, Sara R.A. Wijnant, Edwin K. Silverman, Christian Gieger, Jennie Hui, Andrew P. Morris, James P. Cook, Michael J. McGeachie, Dawn L. DeMeo, Nick Shrine, Traci M. Bartz, Amund Gulsvik, Deborah A. Meyers, Katherine A. Kentistou, Igor Rudan, Jian'an Luan, Ian J. Deary, Catherine John, Michael H. Cho, Lars Lind, Marjo-Riitta Järvelin, Ah Ra Do, Terho Lehtimäki, Stephen S. Rich, Bruce M. Psaty |
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| Přispěvatelé: | Tampere University, Department of Clinical Physiology and Nuclear Medicine, Clinical Medicine, Department of Clinical Chemistry, Epidemiology, Pulmonary Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty AMERICAN THORACIC SOCIETY Vital Capacity LOCI Genome-wide association study EMPHYSEMA Cohort Studies 03 medical and health sciences FEV1/FVC ratio Pulmonary Disease Chronic Obstructive 0302 clinical medicine Risk Factors Internal medicine Forced Expiratory Volume adult case-control studies cohort studies female forced expiratory volume genome-wide association study humans male middle aged phenotype pulmonary disease chronic obstructive risk factors vital capacity Medicine and Health Sciences medicine COPD Humans SMOKING-BEHAVIOR 030212 general & internal medicine GENOME-WIDE ASSOCIATION FAMILIAL AGGREGATION GENETIC EPIDEMIOLOGY Framingham Risk Score HERITABILITY business.industry Case-control study Family aggregation Odds ratio Articles Middle Aged medicine.disease respiratory tract diseases LUNG-FUNCTION Phenotype 030228 respiratory system Genetic epidemiology Case-Control Studies Female 3111 Biomedicine business Genome-Wide Association Study |
| Zdroj: | The Lancet. Respiratory Medicine Moll, M, Sakornsakolpat, P, Shrine, N, Hobbs, B D, DeMeo, D L, John, C, Guyatt, A L, McGeachie, M J, Gharib, S A, Obeidat, M, Lahousse, L, Wijnant, S R A, Brusselle, G, Meyers, D A, Bleecker, E R, Li, X, Tal-Singer, R, Manichaikul, A, Rich, S S, Won, S, Kim, W J, Do, A R, Washko, G R, Barr, R G, Psaty, B M, Bartz, T M, Hansel, N N, Barnes, K, Hokanson, J E, Crapo, J D, Lynch, D, Bakke, P, Gulsvik, A, Hall, I P, Wain, L, Soler Artigas, M, Jackson, V E, Strachan, D P, Hui, J, James, A L, Kerr, S M, Polasek, O, Vitart, V, Marten, J, Rudan, I, Kähönen, M, Surakka, I, Gieger, C, Karrasch, S, Rawal, R, Schulz, H, Deary, I J, Harris, S E, Enroth, S, Gyllensten, U, Imboden, M, Probst-Hensch, N M, Lehtimäki, T, Raitakari, O T, Langenberg, C, Luan, J, Wareham, N, Zhao, J H, Hayward, C, Murray, A, Porteous, D J, Smith, B H, Jarvelin, M R, Wielscher, M, Joshi, P K, Kentistou, K A, Timmers, P RHJ, Wilson, J F, Cook, J P, Lind, L, Mahajan, A, Morris, A P, Ewert, R, Homuth, G, Stubbe, B, Weiss, S, Zeggini, E, Weiss, S T, Silverman, E K, Dudbridge, F, Tobin, M D & Cho, M H 2020, ' Chronic obstructive pulmonary disease and related phenotypes : polygenic risk scores in population-based and case-control cohorts ', The Lancet Respiratory Medicine, vol. 8, no. 7, pp. 696-708 . https://doi.org/10.1016/S2213-2600(20)30101-6 LANCET RESPIRATORY MEDICINE Lancet Resp. Med. 8, 696-708 (2020) The Lancet Respiratory Medicine, 8(7), 696-708. Elsevier Ltd. |
| ISSN: | 2213-2619 2213-2600 |
| Popis: | Background: Genetic factors influence chronic obstructive pulmonary disease (COPD) risk, but the individual variants that have been identified have small effects. We hypothesised that a polygenic risk score using additional variants would predict COPD and associated phenotypes. Methods: We constructed a polygenic risk score using a genome-wide association study of lung function (FEV1 and FEV1/forced vital capacity [FVC]) from the UK Biobank and SpiroMeta. We tested this polygenic risk score in nine cohorts of multiple ethnicities for an association with moderate-to-severe COPD (defined as FEV1/FVC 1 |
| Databáze: | OpenAIRE |
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