Cross-talk between the dipeptidyl peptidase-4 and stromal cell-derived factor-1 in stem cell homing and myocardial repair: Potential impact of dipeptidyl peptidase-4 inhibitors
Autor: | Marina Deljanin-Ilic, R. Kocic, Andrija Smelcerovic, Katarina Tomovic, Marko Anderluh, Gordana Kocic |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Proteases Stromal cell Angiogenesis Dipeptidyl Peptidase 4 Myocardial Infarction 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Glucose homeostasis Animals Humans Pharmacology (medical) Stromal cell-derived factor 1 Progenitor cell Dipeptidyl peptidase-4 Pharmacology Dipeptidyl-Peptidase IV Inhibitors biology Myocardium Stem Cells Endothelial Cells Chemokine CXCL12 Cell biology 030104 developmental biology Endocrinology Glucose biology.protein Stem cell Peptide Hydrolases |
Zdroj: | Pharmacologytherapeutics. 167 |
ISSN: | 1879-016X |
Popis: | Dipeptidyl peptidase-4 (DPP-4), glycyl-prolyl-naphthylamidase, is a serine protease that catalyzes the hydrolysis of various proline-containing polypeptides. It is involved in the inactivation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), having in this way a profound influence on glucose metabolism. During organ damage, stromal and endothelial cells produce a chemokine known as stromal cell-derived factor-1 (SDF-1), a powerful chemoattractant of stem/progenitor cells. SDF-1 binds to a specific α-chemokine receptor (CXCR4) and can be degraded by proteases, including matrix DPP-4/CD26, presented in the circulation, or activated in injured tissues. DPP-4 inhibition has received considerable attention because of its significant therapeutic benefits in the regulation of insulin secretion and tissue insulin sensitivity, the regulation of tumor growth and metastasis, angiogenesis, tissue repair, especially after myocardial infarction, and regulation of endocrine function. Inhibition of circulating proteases appears to maintain the optimal endogenous SDF-1 concentration and may enhance homing of endothelial progenitor cells. In the present article, we present an overview of some basic facts about the role of DPP-4 in glucose homeostasis, the mechanism of its inhibition, and a brief summary of available DPP-4 inhibitors. Furthermore, since protection against the overactivity of proteases is important for restorating cardiac function and repair after myocardial damage, necrosis and apoptosis, we propose that administration of a DPP-4 inhibitor may also be beneficial following myocardial infarction by the prevention of cleavage of stem cell chemoattractant cytokine SDF-1. |
Databáze: | OpenAIRE |
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