Characterization of the Antihistamines Tripelennamine, Methapyrilene, and Thenyldiamine and Their N-Oxides by Thermospray Mass Spectrometry
| Autor: | T.A. Getek, James P. Freeman, Eugene B. Hansen, Walter A. Korfmacher, Claude L. Holder |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Chemical Health and Safety
Chromatography Pyridines Thenyldiamine Health Toxicology and Mutagenesis Methapyrilene Aminopyridines Thermospray Ethylenediamine Toxicology Mass spectrometry Gas Chromatography-Mass Spectrometry Analytical Chemistry Tripelennamine chemistry.chemical_compound chemistry Histamine H1 Antagonists medicine Environmental Chemistry Pyrilamine Ammonium acetate medicine.drug |
| Zdroj: | Journal of Analytical Toxicology. 13:94-96 |
| ISSN: | 1945-2403 0146-4760 |
| DOI: | 10.1093/jat/13.2.94 |
| Popis: | mass spectrometry in the column bypass mode and with 0.1M ammonium acetate/methanol (80:20, v/v) as the mobile phase. Typically, the parent antihistamines produced only (MH)' ions under these conditions. The N-oxides provided strong (MH)' ions and multiple fragment ions. A scheme to explain the fragmentation patterns is proposed. metabolites of compounds of toxicological interest. The N- oxides have been found to be one of the major types of non- conjugated metaholites of various antihistamines (6-8). Therefore, it is important that any analytical method for the analysis of the metabolites of antihistamines performs well for the N-oxides of these compounds. Korfmacher et al. (19) have shown recently that TSMS is a useful technique for the analysis of doxylamine, pyrilamine, and several of their metabolites, in- cluding their N-oxides. The decision to investigate the TSMS methodology for the analysis of other antihistamines and their N-oxide derivatives was based on those results. This report describes the TSMS analysis of three ethylenediamine an- tihistamines and their N-oxides and compares the results to those previously reported for the TSMS analysis of pyrilamine. |
| Databáze: | OpenAIRE |
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