Early and late mortality in hospitalised patients with raised cardiac troponin T
| Autor: | Reza Ashrafi, Derek R. Robinson, Touran Heidi Keen, Peter Sze Chai Wong, Upul Wickramarachchi, Julia Jones, Omer Khanzada |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Acute coronary syndrome Prognostic variable Time Factors Kaplan-Meier Estimate Gastroenterology Liver disease Troponin T Predictive Value of Tests Internal medicine Epidemiology medicine Humans Hospital Mortality Acute Coronary Syndrome Intensive care medicine Aged Aged 80 and over Unstable angina business.industry Proportional hazards model General Medicine Middle Aged Prognosis musculoskeletal system medicine.disease Log-rank test England Heart failure Regression Analysis Female business Biomarkers Follow-Up Studies |
| Zdroj: | Postgraduate Medical Journal. 88:437-442 |
| ISSN: | 1469-0756 0032-5473 |
| DOI: | 10.1136/postgradmedj-2011-130466 |
| Popis: | Aims Cardiac troponins are measured in acute coronary syndrome (ACS) and other conditions. The authors investigate the prognostic significance of cardiac troponin T (TnT) test and comorbid medical conditions. Methods Consecutive patients admitted to the Aintree University Hospital, Liverpool, between 2 January 2004 and 29 February 2004 who had TnT measurement were included. Patients were separated into normal ( Results Of 1021 patients, 313 had raised TnT (195 ACS, 118 non-ACS) and 708 normal TnT (80 ACS, 628 non-ACS). Age (HR 1.06; 95% CI 1.05 to 1.07), congestive cardiac failure (HR 1.37; 95% CI 1.11 to 1.69), cerebrovascular disease (HR 1.37; 95% CI 1.10 to 1.71), chronic obstructive airway disease (HR 1.44; 95% CI 1.19 to 1.75), liver disease (HR 4.16; 95% CI 2.37 to 7.31), renal disease (HR 1.83; 95% CI 1.27 to 2.64), tumour (HR 1.39; 95% CI 1.07 to 1.79), lymphoma (HR 4.81; 95% CI 2.07 to 11.16), metastatic cancer (HR 3.55; 95% CI 2.32 to 5.45) and a higher Charlson's comorbidity score (HR 1.20, 95% CI 1.13 to 1.26) were adverse predictors. Both raised TnT with ACS (HR 1.92, 95% CI 1.54 to 2.39) and raised TnT with non-ACS (HR 2.37, 95% CI 1.87 to 3.00) were associated with worse survival. Raised TnT with non-ACS had a worse survival than raised TnT with ACS (p=0.001). Conclusion Hospitalised patients with raised TnT levels from any cause predicted a higher mortality than normal TnT, with worst survival in those without an obvious ACS. |
| Databáze: | OpenAIRE |
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