Tumor treating fields (TTF) treatment enhances radiation-induced apoptosis in pancreatic cancer cells
| Autor: | Eun Bin Joo, Myonggeun Yoon, Yunhuiv Jo, Geon Oh, Suk Joong Lee, Yongha Gi, Heehun Sung |
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| Rok vydání: | 2020 |
| Předmět: |
endocrine system
Cell Survival medicine.medical_treatment Cancer therapy Apoptosis Electric Stimulation Therapy 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Cell Line Tumor Pancreatic cancer Humans Medicine Radiology Nuclear Medicine and imaging Radiation induced apoptosis Radiological and Ultrasound Technology business.industry Cancer respiratory system medicine.disease Combined Modality Therapy Pancreatic Neoplasms Radiation therapy 030220 oncology & carcinogenesis Cancer research Combined therapy business |
| DOI: | 10.6084/m9.figshare.13177037.v1 |
| Popis: | Tumor treating fields (TTF) therapy is a noninvasive method that uses alternating electric fields to treat various types of cancer. This study demonstrates the combined effect of TTF and radiotherapy (RT) in vitro on pancreatic cancer, which is known to be difficult to treat. In CFPAC-I and HPAF-II pancreatic cancer cell lines, the combined in vitro effect of TTF and RT was evaluated by measuring cell counts, markers of apoptosis, and clonogenic cell survival. The synergy effects were verified using the Valeriote and Carpentier equations. TTF and RT inhibited cancer cell growth more effectively than did monotherapy with TTF or RT. The combined treatment also enhanced apoptosis more than monotherapy, as shown by assays for cleaved poly (ADP-ribose) polymerase (PARP) and annexin V. In addition, on the survival curve, this treatment method has been shown to work synergistically. These results suggest that combined treatment with TTF and RT may be a good alternative treatment for patients with pancreatic cancer. |
| Databáze: | OpenAIRE |
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