Acquisition of different carbapenem resistance mechanisms by an epidemic clonal lineage of Pseudomonas aeruginosa
| Autor: | Lucilla Dolzani, Cristina Lagatolla, Gian Maria Rossolini, R. Spinelli, Elisabetta Edalucci, E. Angelo Tonin, M. Letizia Riccio, Véronique Dubois |
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| Přispěvatelé: | Edalucci, E, Spinelli, R, Dolzani, Lucilla, Riccio, Ml, Dubois, V, Tonin, ENRICO ANGELO, Rossolini, Gm, Lagatolla, Cristina |
| Jazyk: | angličtina |
| Předmět: |
Microbiology (medical)
DNA Bacterial Carbapenem Lineage (genetic) Carbapenem resistance metallo-β-lactamase Molecular Sequence Data carbapenem resistance Porins Microbial Sensitivity Tests Biology medicine.disease_cause Integron beta-Lactamases Microbiology Disease Outbreaks Integrons resistance acquisition Drug Resistance Bacterial medicine Humans Pseudomonas Infections Antibacterial agent Molecular Epidemiology Molecular epidemiology Pseudomonas aeruginosa VIM-2 epidemic clonal lineage Outbreak General Medicine Sequence Analysis DNA biochemical phenomena metabolism and nutrition clonal lineage bacterial infections and mycoses DNA Fingerprinting Infectious Diseases DNA profiling Carbapenems Italy biology.protein France Polymorphism Restriction Fragment Length medicine.drug |
| Zdroj: | Clinical Microbiology and Infection. (1):88-90 |
| ISSN: | 1198-743X |
| DOI: | 10.1111/j.1469-0691.2007.01874.x |
| Popis: | Multidrug-resistant isolates of a clonal lineage of Pseudomonas aeruginosa producing the VIM-2 metallo-β-lactamase (MBL), involved in a large outbreak in an Italian hospital, were compared with MBL-negative strains that had caused outbreaks in two French hospitals. Although the isolates had different carbapenem MICs, the VIM-2-producing isolates from Italy carried identical, or very similar, allelic forms of the oprD gene, harboured a common class 1 integron, belonged to the same multilocus sequence type (ST111), and showed macrorestriction profiles that were related to those of the MBL-negative French strains. These results support the concept of independent acquisition of resistance determinants by members of a widespread clonal lineage of P. aeruginosa. |
| Databáze: | OpenAIRE |
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