The 5-HTTLPR polymorphism impacts moral permissibility of impersonal harmful behaviors
| Autor: | Xiaocai Gao, Linlin He, Yafang Yang, Mengying Xue, Rongjun Yu, Wenxuan Guo, Mengfei Zhang, Chunlan Wang, Xiaohan Li, Pingyuan Gong |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Serotonin impersonal harm Synaptic cleft Genotype Cognitive Neuroscience Emotions Experimental and Cognitive Psychology Original Manuscript Morals 050105 experimental psychology personal harm serotonin transporter gene Developmental psychology cross-sectional analysis 03 medical and health sciences Judgment 0302 clinical medicine two-wave comparison Humans 0501 psychology and cognitive sciences Serotonin transporter Alleles Serotonin Plasma Membrane Transport Proteins Polymorphism Genetic biology 05 social sciences General Medicine moral judgment 5 httlpr polymorphism Cross-Sectional Studies Cohort biology.protein Female Psychology 030217 neurology & neurosurgery |
| Zdroj: | Social Cognitive and Affective Neuroscience |
| ISSN: | 1749-5024 1749-5016 |
| Popis: | Inspired by the roles of serotonin in an emotional aversion to harmful actions, we examined to what extent serotonin transporter gene (5-HTT)–linked polymorphic region (5-HTTLPR), a proxy for measuring serotonin function, underpinned the individual differences in moral judgment through cross-sectional analysis and two-wave comparison. The cross-sectional analysis with a larger cohort (N = 1197) showed that the SS carriers of the 5-HTTLPR polymorphism, corresponding to the low ratio of serotonin recycling from the synaptic cleft, rated impersonal harmful actions (e.g. flipping a switch to divert a train to hit one person instead of five people) as more permissible as compared with the L-allele carriers. The two-wave comparison with a subsample from the larger cohort (N = 563) indicated that the association between 5-HTTLPR polymorphism and moral permissibility of impersonal harmful actions was stable from wave 1 to wave 2. Thus, these findings highlight the importance of the 5-HTTLPR polymorphism to harmful moral behaviors. |
| Databáze: | OpenAIRE |
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