Influence of structural elements on iron(III) chelating properties in a new series of amino acid-derived monohydroxamates
| Autor: | Elzbieta Gumienna-Kontecka, Agnieszka Szebesczyk, Jenny Besserglick, Evgenia Olshvang |
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| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Chemistry Stereochemistry Siderophores 010402 general chemistry 01 natural sciences 0104 chemical sciences Amino acid Inorganic Chemistry chemistry.chemical_compound Hydroxamates Fe(III) complexes Functional group Polymer chemistry Materials Chemistry medicine Ferric Chelation Physical and Theoretical Chemistry Stoichiometry medicine.drug |
| Zdroj: | Inorganica Chimica Acta. 473:286-296 |
| ISSN: | 0020-1693 |
| DOI: | 10.1016/j.ica.2017.06.020 |
| Popis: | A series of amino acid-derived monohydroxamate compounds A1 – A7 was synthesized and characterized for their coordination properties of Fe(III). The series varies in their skeletal lengths and compositions; some compounds lack external substituents, others are substituted with external functional amino or carboxylic groups, or alternatively inert methyl. Undertaken investigations allowed the determination of stoichiometry, stability constants and spectroscopic parameters of formed ferric complexes. Incorporation of an external functional group with a dissociable proton affects the coordination behavior; the presence of carboxylic or amino groups hampers the formation of mono-, di- and trihydroxamate ferric complexes of presented compounds. The differences in Fe(III) affinity of the monohydroxamates vs trihydroxamates was reflected by the stability constants and pFe, indicating the superior stability of hexadentate complexes. |
| Databáze: | OpenAIRE |
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