The effect of Plasmodium falciparum malaria on peripheral and placental HIV-1 RNA concentrations in pregnant Malawian women
| Autor: | Malcolm E. Molyneux, Paul E. Wilson, Elizabeth T. Abrams, Deborah D. Kamwendo, Ebbie Chaluluka, Victor Mwapasa, Valentino M. Lema, Stephen J. Rogerson, Eyob Tadesse, Steven R. Meshnick |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Placenta Immunology Population Physiology HIV Infections Parasitemia Pregnancy parasitic diseases medicine Humans Immunology and Allergy Malaria Falciparum Pregnancy Complications Infectious education education.field_of_study biology Plasmodium falciparum Viral Load medicine.disease biology.organism_classification Infectious Disease Transmission Vertical CD4 Lymphocyte Count Cross-Sectional Studies Infectious Diseases medicine.anatomical_structure Lentivirus HIV-1 RNA Viral Gestation Female Viral disease Viral load Malaria |
| Zdroj: | AIDS. 18:1051-1059 |
| ISSN: | 0269-9370 |
| DOI: | 10.1097/00002030-200404300-00014 |
| Popis: | The objective was to investigate the effect of placental Plasmodium falciparum malaria infection on peripheral and/or placental HIV-1 viral load. A cross-sectional study of HIV-infected pregnant women with and without placental malaria delivering at Queen Elizabeth Central Hospital in Malawi. Peripheral blood samples were collected from consenting women and tested for HIV. HIV-infected women received nevirapine at the onset of labor. At delivery placental blood and tissue specimens were collected. HIV-1 RNA concentrations were measured in peripheral and placental plasma samples and malaria infection was determined by placental histopathology. Of the 480 HIV-infected women enrolled 304 had placental histopathology performed of whom 74 (24.3%) had placental malaria. Compared with women without placental malaria those with placental malaria had a 2.5-fold higher geometric mean peripheral HIV-1 RNA concentration (62 359 versus 24 814 copies/ml; P = 0.0007) and a 2.4-fold higher geometric mean placental HIV-1 RNA concentration (11 733 versus 4919 copies/ml; P = 0.008). In multivariate analyses after adjusting for CD4 cell count and other covariates placental malaria was associated with a 1.7-fold increase in geometric mean peripheral HIV-1 RNA concentration (47 747 versus 27 317 copies/ml; P = 0.02) and a 2.0-fold increase in geometric mean placental HIV-1 RNA concentration (9670 versus 4874 copies/ml; P = 0.03). Placental malaria infection is associated with an increase in peripheral and placental HIV-1 viral load which might increase the risk of mother-to-child transmission of HIV. (authors) |
| Databáze: | OpenAIRE |
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