Chiral Resolution of Mandelic Acid through Preferential Cocrystallization with Nefiracetam

Autor:	Nikolay Tumanov, Johan Wouters, Xavier Buol, Tom Leyssens, Laurent Collard, Camila Caro Garrido, Koen Robeyns
Přispěvatelé:	UCL - SST/IMCN - Institute of Condensed Matter and Nanosciences, UNamur - SCHI_GCPTS (groupe de chimie physique, théorique et structurale)
Rok vydání:	2020
Předmět:	General Chemistry Condensed Matter Physics Mandelic acid Cocrystal Combinatorial chemistry Chiral resolution Drug compound chemistry.chemical_compound chemistry Nefiracetam medicine General Materials Science medicine.drug
Zdroj:	Crystal Growth & Design, Vol. 20, no.12, p. 7979-7988 (2020)
ISSN:	1528-7505 1528-7483
DOI:	10.1021/acs.cgd.0c01236
Popis:	In this paper, we identified a cocrystal conglomerate of mandelic acid using a drug compound as a coformer. We then developed a chiral resolution process based on preferential cocrystallization. Several versions of such a process were explored and optimized, leading to a successful resolution of mandelic acid, evidencing the efficiency of our system. Excellent enantiopurity (98-99%) was obtained with a process that can run for multiple cycles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8430a31fa3f46deef47832a271c3ed22 https://doi.org/10.1021/acs.cgd.0c01236 Zobrazit plný text záznamu