Maternal dipyrone treatment during lactation in mice reduces maternal behavior and increases anxiety-like behavior in offspring
Autor: | Alexandre Giusti-Paiva, Tatiane Helena Batista, Ana Cláudia Alves Freire Ribeiro, Fabiana C. Vilela, Vanessa Barbosa Veronesi |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Male medicine.medical_specialty Elevated plus maze Offspring Developmental Disabilities Dipyrone Drinking Behavior Anxiety Open field Marble burying 03 medical and health sciences Mice 0302 clinical medicine Developmental Neuroscience Pregnancy Internal medicine Lactation medicine Animals Humans Maternal Behavior Maze Learning Dose-Response Relationship Drug Anti-Inflammatory Agents Non-Steroidal Age Factors Metamizole 030104 developmental biology Endocrinology medicine.anatomical_structure Animals Newborn Prenatal Exposure Delayed Effects Reflex Exploratory Behavior Female medicine.symptom Vocalization Animal Psychology 030217 neurology & neurosurgery Developmental Biology medicine.drug |
Zdroj: | International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 58 |
ISSN: | 1873-474X |
Popis: | Dipyrone (metamizole), a powerful drug, is widely used as an analgesic and antipyretic; however, the safety of its use during lactation and the potential impact on the offspring are not well established. This study aimed to determine the effect of maternal dipyrone treatment during lactation on offspring development and emotional behavior and on the dam’s maternal behavior. Hence, on postnatal day (PND) 2, drinking water only or drinking water containing dipyrone at doses of 100, 300, and 500 mg/kg/day, were offered to lactating mothers up to PND9. Thereafter, all mice were provided regular drinking water. On PND2, all litters were culled to 8 pups (4 males and 4 females). Maternal behavior was evaluated at PND3, 6, 9, and 12, and at PND7 we evaluated locomotor activity in the open field. Reflex parameters and physical development of offspring were evaluated during lactation. At PND7, analysis of ultrasonic vocalization (USV) was performed. When the animals reached adolescence, we evaluated their performance in the open field, elevated plus maze (EPM), and marble burying. Our data demonstrated that maternal dipyrone treatment during lactation not only altered maternal behavior and the onset of physical and neurodevelopmental landmarks but also had an impact on anxiety-like behavior in offspring. |
Databáze: | OpenAIRE |
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