Normative data on cardiovascular autonomic function in Greenlandic Inuit
| Autor: | Stine Byberg, Jesper Fleischer, Christian Stevns Hansen, Marit E. Jørgensen, Trine Louise Jul Larsen, Marie Mathilde Bjerg Christensen, Jens Laursen, Dorte Vistisen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Research design
Male diabetic neuropathies Cross-sectional study Endocrinology Diabetes and Metabolism Autonomic Nervous System Diseases of the endocrine glands. Clinical endocrinology Heart Rate Heart rate Autonomic reflex Medicine Heart rate variability Humans Aged indigenous peoples business.industry heart rate variability diabetes complications Middle Aged RC648-665 Cross-Sectional Studies Inuit Population study Normative Female Epidemiology/Health services research business Body mass index Demography |
| Zdroj: | Christensen, M M B, Hansen, C S, Fleischer, J, Vistisen, D, Byberg, S, Larsen, T, Laursen, J C & Jørgensen, M E 2021, ' Normative data on cardiovascular autonomic function in Greenlandic Inuit ', BMJ Open Diabetes Research and Care, vol. 9, no. 1, e002121 . https://doi.org/10.1136/bmjdrc-2021-002121 BMJ Open Diabetes Research & Care BMJ Open Diabetes Research & Care, Vol 9, Iss 1 (2021) Christensen, M M B, Hansen, C S, Fleischer, J, Vistisen, D, Byberg, S, Larsen, T, Laursen, J C & Jørgensen, M E 2021, ' Normative data on cardiovascular autonomic function in Greenlandic Inuit ', BMJ open diabetes research & care, vol. 9, no. 1, e002121 . https://doi.org/10.1136/bmjdrc-2021-002121 |
| DOI: | 10.1136/bmjdrc-2021-002121 |
| Popis: | IntroductionDiabetes is increasing among Greenlandic Inuit; however, the prevalence of cardiovascular autonomic neuropathy (CAN) is yet unknown. The assessment of CAN requires an ability to differentiate between normal and abnormal. The aim was to establish normative reference data of cardiovascular autonomic function in Greenlandic Inuit.Research design and methodsIn this cross-sectional study, cardiovascular autonomic function was evaluated in participants without diabetes during the Greenlandic Population Study 2018 and in the town Qasigiannguit in 2020. Assessment included cardiovascular autonomic reflex tests (CARTs) and power spectral analysis of heart rate variability (HRV). Normative reference limits were estimated by applying piecewise linear quantile regression models at the fifth percentile. Models were adjusted for age and sex.ResultsBased on examinations of 472 participants (61.7% females), normative reference data was established for all outcomes. Mean age was 54 years (SD 13.1). Higher age was inversely associated with all outcomes of CARTs and HRV. A linear fall in cardiovascular autonomic function tended to level off beyond age of 60 or 70 years for supine-to-upright position ratio and low frequency power. However, the number of observations in subjects older than 60 or 70 years was limited, which may have caused a flattening of the curve around that age. No other associations were found.ConclusionsThe general level of the CARTs and HRV for all age groups is notably lower than in previous studies from other nationalities. We speculate that sociodemographic and cultural aspects of the Greenlandic Inuit population including body mass index, smoking, physical activity and alcohol consumption may have affected the cardiovascular autonomic function. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|