What is natural in natural killer cells?
| Autor: | Eric Vivier |
|---|---|
| Přispěvatelé: | Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Cytotoxicity
Immunologic MESH: Killer Cells Natural Immunology Biology MESH: Histocompatibility Antigens Class I Interleukin 21 Mice NK-92 MHC class I Immunology and Allergy Cytotoxic T cell Animals Humans MESH: Animals MESH: Cytotoxicity Immunologic MESH: Mice MESH: Immunity Natural Lymphokine-activated killer cell Innate immune system MESH: Humans Histocompatibility Antigens Class I MESH: Antigens CD56 Natural killer T cell CD56 Antigen Immunity Innate Killer Cells Natural Self Tolerance MESH: Self Tolerance biology.protein Interleukin 12 [SDV.IMM]Life Sciences [q-bio]/Immunology |
| Zdroj: | Immunology Letters Immunology Letters, Elsevier, 2006, 107 (1), pp.1-7. ⟨10.1016/j.imlet.2006.07.004⟩ Immunology Letters, 2006, 107 (1), pp.1-7. ⟨10.1016/j.imlet.2006.07.004⟩ |
| ISSN: | 0165-2478 |
| DOI: | 10.1016/j.imlet.2006.07.004⟩ |
| Popis: | Denomination is a not a trivial issue in human activities in general, and in science in particular. Natural killer (NK) cells have been originally characterized as cytolytic effector lymphocytes present in mouse spleen and human peripheral blood. The "NK" name was originally coined after the NK cell's ability to kill targets cells without requirement for a prior exposure to these targets, in contrast to cytolytic T cells (Kiessling, R., Klein, E., Wigzell, H. 1975. "Natural" killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype. Eur J Immunol 5:112-117). In this review, an attempt is made to revisit the basis for this vastly admitted definition of NK cells, and to enumerate some of the unsolved questions related to NK cell biology. An emphasis will be given to recent data showing that circulating NK cells are not steady state killers unless they have gone through a process of functional maturation. This process that is referred as to "NK cell education" thereafter involves self MHC class I recognition via inhibitory receptors, but also some still unidentified factors. Therefore, the NK denomination does not reflect a genuine property of these lymphocytes that appear to more and more resemble T and B lymphocytes. |
| Databáze: | OpenAIRE |
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