Iron bis-glycine chelate competes for the nonheme-iron absorption pathway
| Autor: | Dora Inés Mazariegos, Virginia Gidi, Miguel Arredondo, Fernando Pizarro, Eva Hertrampf, Angélica Letelier, Manuel Olivares |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Absorption (pharmacology) Iron Inorganic chemistry Glycine Biological Availability Nutritional Status Medicine (miscellaneous) Iron Chelating Agents Binding Competitive Intestinal absorption Absorption Ferrous Hemoglobins chemistry.chemical_compound Humans Chelation Ferrous Compounds Sulfate Heme Nutrition and Dietetics Chemistry Intestinal Absorption Female Hemoglobin Nuclear chemistry |
| Zdroj: | The American Journal of Clinical Nutrition. 76:577-581 |
| ISSN: | 0002-9165 |
| Popis: | Background: The enterocytic absorption pathway of the food fortificant iron bis-glycine chelate has been the subject of controversy because it is not clear whether that substance uses the classic nonheme-iron absorption pathway or a pathway similar to that of heme absorption. Objective: The objective was to study the absorption pathway of iron bis-glycine chelate in human subjects. Design: Eighty-five healthy adult women were selected to participate in 1 of 6 iron-absorption studies. Study A involved the measurement of the dose-response curve of the absorption of ferrous sulfate (through a nonheme-iron absorption pathway); study B involved the competition of iron bis-glycine chelate with ferrous sulfate for the nonheme-iron absorption pathway; study C involved the measurement of the dose-response curve of heme-iron absorption; study D involved the competition of iron bis-glycine chelate with hemoglobin for the heme-iron absorption pathway; and studies E and F were the same as studies A and B, except that the iron bis-glycine chelate was encapsulated in enteric gelatin capsules so that it would not be processed in the stomach. Results: Iron from the bis-glycine chelate competed with ferrous sulfate for the nonheme-iron absorption pathway. Iron from the bis-glycine chelate also competed with ferrous sulfate for absorption when liberated directly into the intestinal lumen. Iron from the bis-glycine chelate did not compete with heme iron for the heme-iron absorption pathway. Conclusion: The iron from iron bis-glycine chelate delivered at the level of the stomach or duodenum becomes part of the nonheme-iron pool and is absorbed as such. |
| Databáze: | OpenAIRE |
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