Botulinum Toxin A Treatment for Primary and Secondary Raynaud's Phenomenon in Teenagers
| Autor: | Raúl de Lucas Laguna, Marta Feito Rodríguez, Clara Chiloeches Fernández, Rocío Maseda Pedrero, Lucía Quintana Castanedo, Daniel Nieto Rodríguez |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Adolescent Sedation Dermatology Injections Botulinum toxin a 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Humans Pain Management Prospective Studies Botulinum Toxins Type A Prospective cohort study Pain Measurement business.industry Gold standard Raynaud Disease Vasospasm General Medicine medicine.disease Botulinum toxin Blockade Neuromuscular Agents 030220 oncology & carcinogenesis Anesthesia Anesthetic Female Surgery medicine.symptom business medicine.drug |
| Zdroj: | Dermatologic Surgery. 47:61-64 |
| ISSN: | 1524-4725 1076-0512 |
| DOI: | 10.1097/dss.0000000000002397 |
| Popis: | Background Raynaud's phenomenon (RP) is a clinical syndrome characterized by recurrent episodes of digital vasospasm triggered by exposure to physical and chemical agents or emotional stress. Although many pharmacologic treatments have been tested, there is still no cure or gold standard therapy. Botulinum toxin treatment has been proved to reduce pain and increase arterial blood flow in treated hands of adult patients with RP. Objective The aim of this study is to evaluate the efficacy of botulinum toxin A on younger than 18-year-old patients with primary and secondary RP. Materials and methods A single-center prospective study was performed, including 8 patients aged 14 to 17 years who were clinically diagnosed with primary or secondary RP. BTX was injected into each hand without sedation or anesthetic blockade. The primary outcome was pain reduction after BTX injection. Pain intensity was evaluated at baseline and in the first follow-up. Secondary outcomes included variations in the number and severity of RP episodes after the BTX injection. Results All patients stated significant pain reduction and decreased cold sensitivity, except one patient who did not feel any changes. No patients reported any loss of strength on thumb-index finger. Conclusion BTX injection is a simple, noninvasive, and cost-effective treatment alternative, offering an important nonsurgical therapeutic option for the pediatric population. It could also help optimize the dose of other treatments used in these patients. The most commonly observed positive effect is a reduction in the pain associated with RP attacks. Further studies are needed to confirm these results. |
| Databáze: | OpenAIRE |
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