Long-term follow-up of autoimmune thrombocytopenic purpura (ATP) patients submitted to splenectomy
| Autor: | Carla Felici, M. C. Arista, M. Peraino, Elvira Macale, Antonio Chistolini, Maria Gabriella Mazzucconi, Giuseppe Maria Gandolfo, Vittorio Francavilla, Laura Conti |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Time Factors Adolescent Long term follow up medicine.medical_treatment Splenectomy Autoimmune thrombocytopenic purpura Disease-Free Survival Immunopathology Overall survival Medicine Humans Platelet autoimmune thrombocytopenic purpura autoimmune thrombocytopenic purpura splenectomy splenectomy Autoimmune disease Purpura Thrombocytopenic Idiopathic Adult patients business.industry Hematology General Medicine Middle Aged medicine.disease Surgery Immunoglobulin G Prednisone Female business Follow-Up Studies |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0902-4441 |
| Popis: | We studied the general outcome in 94 adult patients with autoimmune thrombocytopenic purpura (ATP) submitted to splenectomy. Of 84/94 patients who presented a complete or partial response 30 d after splenectomy, 16 (19%) showed one or more relapses. The clinical situation of the 81 patients still under observation is as follows: 13 unrensponsive, 60 completely or partially responsive, without relapses during the follow-up, 8 completely or partially responsive after one or more relapses. No correlation was found between the favourable splenectomy outcome and age at splenectomy, the diagnosis-splenectomy interval and initial response to corticosteroids. The probability of disease-free survival is 83%, projected at 10 yr, while the overall survival is 93%, projected at 10 yr. PAIgG levels of the normal subjects and of responding patients were found to be similar, while in the groups of non-responding/relapsing patients, significantly higher values of PAIgG were detected, as compared to the control group. |
| Databáze: | OpenAIRE |
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