Effect of substance P and Met-Enkephalin on cat colonic smooth muscle activity
| Autor: | E. Atanassova, M. Papasova |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Met-enkephalin
medicine.medical_specialty Colon Enkephalin Methionine Neuropeptide Substance P In Vitro Techniques Peptide hormone Biology chemistry.chemical_compound Internal medicine medicine Carnivora Animals Pharmacology Naloxone Fissipedia Muscle Smooth Biological activity biology.organism_classification Endocrinology chemistry Cats medicine.symptom Muscle Contraction Muscle contraction |
| Zdroj: | General Pharmacology: The Vascular System. 27:1053-1056 |
| ISSN: | 0306-3623 |
| DOI: | 10.1016/0306-3623(95)02132-9 |
| Popis: | 1. 1. The effects of substance P (2.5×10−8 M) (SP) and met-enkephalin (10−7 M) (ME), when administered alone or in combination (SP+ME), on the contractile activity of cat colonic muscle strips were compared. 2. 2. SP evoked powerful contractions of the circular muscle strips (2.30±0.36 g) (background 0.65±0.10 g). 3. 3. In the majority of cases, ME significantly increased the background activity (1.88±0.34 g and 0.70±0.10 g, respectively). 4. 4. The two substances administered together produced the most pronounced contractile activity (3.86±0.44 g). 5. 5. The longitudinal muscle strips showed higher spontaneous and evoked contractions. 6. 6. Thus ME contributes to the increase in the effect of SP on colonic contractile activity. |
| Databáze: | OpenAIRE |
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