Adenosine and angiotensin system interact in the regulation of renal microcirculation in humans
| Autor: | Luca Serasini, Silvio Fedele, Mario Marzilli, Enri Gliozheni, Goran Djukic, Enrico Orsini, A. Mazzarisi, Antonio L'Abbate, Paolo Marraccini |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Mean arterial pressure Adenosine Angiotensins Captopril Angiotensin-Converting Enzyme Inhibitors Renal Circulation medicine.artery Internal medicine medicine Humans Drug Interactions Renal artery Mean Blood Flow Velocity Pharmacology Kidney Analysis of Variance Chemistry Microcirculation Middle Aged medicine.anatomical_structure Endocrinology Renal blood flow ACE inhibitor Female Cardiology and Cardiovascular Medicine medicine.drug |
| Zdroj: | Journal of cardiovascular pharmacology. 35(5) |
| ISSN: | 0160-2446 |
| Popis: | We sought to evaluate the possible interaction between the adenosine and angiotensin systems in the regulation of renal microcirculation in humans. Twenty normotensive patients entered the study. Ten patients (group 1) were pretreated with 50 mg of captopril, an inhibitor of angiotensin-converting enzyme, whereas 10 patients (group 2) were pretreated with placebo. Incremental doses of adenosine (from 10 -5 to I mg) were injected into a renal artery to all patients at 5-min intervals. Adenosine injection reduced mean renal blood flow velocity in both groups (from 17.3 ± 2.8 and 16.7 ± 2 cm/s to 5.1 ± 1.1 and 3.8 ± 0.8 cm/s. in groups 1 and 2, respectively). The decrease in flow velocity was immediate after adenosine, and its duration was proportional to dosage (y = 3.05 x -2.7; R 2 = 0.46; p < 0.01). However, group I had a slope of regression lower than group 2 (2.37 vs. 3.82 s; p < 0.03). The index of renal resistance (mean arterial pressure/mean blood flow velocity) increased linearly in both groups with adenosine, but group 1 showed a lower slope of increment (2.77 vs. 5.57 mm Hg/cm/s; p < 0.01). Adenosine administration induced a marked and transient increase in human renal resistance. This vasoconstrictive effect of adenosine was blunted by captopril pretreatment. |
| Databáze: | OpenAIRE |
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