Complex karyotype in de novo acute myeloid leukemia: typical and atypical subtypes differ molecularly and clinically
| Autor: | Jonathan E. Kolitz, William Blum, Christopher J. Walker, Ann-Kathrin Eisfeld, Jessica Kohlschmidt, James S. Blachly, Dimitrios Papaioannou, Deedra Nicolet, Geoffrey L. Uy, Eunice S. Wang, Marius Bill, Richard Stone, Krzysztof Mrózek, Bayard L. Powell, Clara D. Bloomfield, Andrew J. Carroll, John C. Byrd |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine complex karyotype Cancer Research Myeloid clinical outcome Gastroenterology 0302 clinical medicine hemic and lymphatic diseases Chromosomes Human Aged 80 and over Myeloid leukemia Hematology Middle Aged Prognosis 3. Good health Gene Expression Regulation Neoplastic Survival Rate Leukemia Myeloid Acute Leukemia medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Female Abnormality Nucleophosmin Adult medicine.medical_specialty NPM1 Adolescent acute myeloid leukemia Article MED12 Young Adult 03 medical and health sciences Internal medicine Complex Karyotype Biomarkers Tumor medicine Humans Survival rate Aged gene mutations Chromosome Aberrations business.industry medicine.disease 030104 developmental biology Karyotyping Mutation next-generation sequencing business Follow-Up Studies |
| Zdroj: | Leukemia |
| ISSN: | 1476-5551 0887-6924 |
| Popis: | Complex karyotype (CK) with ≥ 3 abnormalities is detected in 10–12% of patients with acute myeloid leukemia (AML) and associated with poor prognosis. The most common unbalanced abnormalities found in CK result in loss of material from the 5q, 7q, and/or 17p chromosome arms. The presence of 5q, 7q, and/or 17p abnormalities denotes typical CK and their absence denotes atypical CK. Since molecular features of CK-AML are not well characterized, we investigated mutational status of 81 leukemia/cancer-associated genes in 160 clinically well-characterized patients. They included 136 patients with ≥ 3 exclusively unbalanced chromosome abnormalities, 96 of whom had a typical CK and 40 atypical CK, and 24 patients with ≥ 1 balanced abnormality in addition to ≥ 2 unbalanced ones. Patients with atypical CK-AML differed from those with typical CK-AML: they carried TP53 mutations less often (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink